Subregion-specific decreases in hippocampal serotonin transporter protein expression and function associated with endophenotypes of depression

• Published in: Hippocampus Vol. 24; no. 4; pp. 493 - 501
• Main Authors: Tang, Man, He, Tao, Sun, Xiao, Meng, Qing-Yan, Diao, Yao, Lei, Jie-Yu, He, Xiao-Jing, Chen, Lei, Sang, Xiu-Bo, Zhao, Shulei
• Format: Journal Article
• Language: English
• Published: United States Blackwell Publishing Ltd 01.04.2014; Wiley Subscription Services, Inc
• Subjects: Adrenal Cortex Hormones; anhedonia; Anhedonia - physiology; Animals; behavioral despair; CA1 Region, Hippocampal - metabolism; CA3 Region, Hippocampal - metabolism; corticosteroid; Dentate Gyrus - metabolism; Dentate Gyrus - pathology; Depressive Disorder - metabolism; Depressive Disorder - pathology; Disease Models, Animal; Endophenotypes; hippocampus; Hippocampus - metabolism; Male; Mice; Mice, Inbred Strains; Organ Size; Random Allocation; Serotonin - metabolism; Serotonin Plasma Membrane Transport Proteins - metabolism; synaptosomal 5-HT uptake; Synaptosomes - metabolism; corticosteroid; behavioral despair; hippocampus; synaptosomal 5-HT uptake; anhedonia

ABSTRACT Stress influences the development of depression, and depression is associated with structural and functional changes in the hippocampus. The current study sought to determine whether chronic corticosteroid (CORT) treatment influences serotonin transporter (5‐HTT) protein expression and func...