Subregion-specific decreases in hippocampal serotonin transporter protein expression and function associated with endophenotypes of depression

ABSTRACT Stress influences the development of depression, and depression is associated with structural and functional changes in the hippocampus. The current study sought to determine whether chronic corticosteroid (CORT) treatment influences serotonin transporter (5‐HTT) protein expression and func...

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Published inHippocampus Vol. 24; no. 4; pp. 493 - 501
Main Authors Tang, Man, He, Tao, Sun, Xiao, Meng, Qing-Yan, Diao, Yao, Lei, Jie-Yu, He, Xiao-Jing, Chen, Lei, Sang, Xiu-Bo, Zhao, Shulei
Format Journal Article
LanguageEnglish
Published United States Blackwell Publishing Ltd 01.04.2014
Wiley Subscription Services, Inc
Subjects
Adrenal Cortex Hormones
anhedonia
Anhedonia - physiology
Animals
behavioral despair
CA1 Region, Hippocampal - metabolism
CA3 Region, Hippocampal - metabolism
corticosteroid
Dentate Gyrus - metabolism
Dentate Gyrus - pathology
Depressive Disorder - metabolism
Depressive Disorder - pathology
Disease Models, Animal
Endophenotypes
hippocampus
Hippocampus - metabolism
Male
Mice
Mice, Inbred Strains
Organ Size
Random Allocation
Serotonin - metabolism
Serotonin Plasma Membrane Transport Proteins - metabolism
synaptosomal 5-HT uptake
Synaptosomes - metabolism
corticosteroid
behavioral despair
hippocampus
synaptosomal 5-HT uptake
anhedonia
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Abstract ABSTRACT Stress influences the development of depression, and depression is associated with structural and functional changes in the hippocampus. The current study sought to determine whether chronic corticosteroid (CORT) treatment influences serotonin transporter (5‐HTT) protein expression and function in the CA1, CA3, and dentate gyrus (DG) subregions of the hippocampus. Male CD‐1 mice were subcutaneously injected with CORT at a dose of 20 mg/kg once daily for 3 weeks. Behavioral state was assessed using sucrose preference, physical state of the coat, forced swimming test, and tail suspension test. We then determine 5‐HTT protein expression and synaptosomal 5‐HT uptake in the CA1, CA3 and DG subregions. CORT treatment induced anhedonia and behavioral despair, two core endophenotypes of clinical depression; 5‐HTT protein expression levels and synaptosomal 5‐HT uptake were both decreased in a subregion‐specific manner, with the greatest decrease observed in the DG, a moderate decrease in the CA3, and the CA1 showed no apparent change. In addition, a reduction in tissue mass was detected in the DG following the CORT treatment. These data indicate that subregion‐specific decreases in hippocampal 5‐HTT protein expression and function are associated with endophenotypes of depression. © 2014 Wiley Periodicals, Inc.
AbstractList Stress influences the development of depression, and depression is associated with structural and functional changes in the hippocampus. The current study sought to determine whether chronic corticosteroid (CORT) treatment influences serotonin transporter (5-HTT) protein expression and function in the CA1, CA3, and dentate gyrus (DG) subregions of the hippocampus. Male CD-1 mice were subcutaneously injected with CORT at a dose of 20 mg/kg once daily for 3 weeks. Behavioral state was assessed using sucrose preference, physical state of the coat, forced swimming test, and tail suspension test. We then determine 5-HTT protein expression and synaptosomal 5-HT uptake in the CA1, CA3 and DG subregions. CORT treatment induced anhedonia and behavioral despair, two core endophenotypes of clinical depression; 5-HTT protein expression levels and synaptosomal 5-HT uptake were both decreased in a subregion-specific manner, with the greatest decrease observed in the DG, a moderate decrease in the CA3, and the CA1 showed no apparent change. In addition, a reduction in tissue mass was detected in the DG following the CORT treatment. These data indicate that subregion-specific decreases in hippocampal 5-HTT protein expression and function are associated with endophenotypes of depression.Stress influences the development of depression, and depression is associated with structural and functional changes in the hippocampus. The current study sought to determine whether chronic corticosteroid (CORT) treatment influences serotonin transporter (5-HTT) protein expression and function in the CA1, CA3, and dentate gyrus (DG) subregions of the hippocampus. Male CD-1 mice were subcutaneously injected with CORT at a dose of 20 mg/kg once daily for 3 weeks. Behavioral state was assessed using sucrose preference, physical state of the coat, forced swimming test, and tail suspension test. We then determine 5-HTT protein expression and synaptosomal 5-HT uptake in the CA1, CA3 and DG subregions. CORT treatment induced anhedonia and behavioral despair, two core endophenotypes of clinical depression; 5-HTT protein expression levels and synaptosomal 5-HT uptake were both decreased in a subregion-specific manner, with the greatest decrease observed in the DG, a moderate decrease in the CA3, and the CA1 showed no apparent change. In addition, a reduction in tissue mass was detected in the DG following the CORT treatment. These data indicate that subregion-specific decreases in hippocampal 5-HTT protein expression and function are associated with endophenotypes of depression.
Stress influences the development of depression, and depression is associated with structural and functional changes in the hippocampus. The current study sought to determine whether chronic corticosteroid (CORT) treatment influences serotonin transporter (5-HTT) protein expression and function in the CA1, CA3, and dentate gyrus (DG) subregions of the hippocampus. Male CD-1 mice were subcutaneously injected with CORT at a dose of 20 mg/kg once daily for 3 weeks. Behavioral state was assessed using sucrose preference, physical state of the coat, forced swimming test, and tail suspension test. We then determine 5-HTT protein expression and synaptosomal 5-HT uptake in the CA1, CA3 and DG subregions. CORT treatment induced anhedonia and behavioral despair, two core endophenotypes of clinical depression; 5-HTT protein expression levels and synaptosomal 5-HT uptake were both decreased in a subregion-specific manner, with the greatest decrease observed in the DG, a moderate decrease in the CA3, and the CA1 showed no apparent change. In addition, a reduction in tissue mass was detected in the DG following the CORT treatment. These data indicate that subregion-specific decreases in hippocampal 5-HTT protein expression and function are associated with endophenotypes of depression.
ABSTRACT Stress influences the development of depression, and depression is associated with structural and functional changes in the hippocampus. The current study sought to determine whether chronic corticosteroid (CORT) treatment influences serotonin transporter (5‐HTT) protein expression and function in the CA1, CA3, and dentate gyrus (DG) subregions of the hippocampus. Male CD‐1 mice were subcutaneously injected with CORT at a dose of 20 mg/kg once daily for 3 weeks. Behavioral state was assessed using sucrose preference, physical state of the coat, forced swimming test, and tail suspension test. We then determine 5‐HTT protein expression and synaptosomal 5‐HT uptake in the CA1, CA3 and DG subregions. CORT treatment induced anhedonia and behavioral despair, two core endophenotypes of clinical depression; 5‐HTT protein expression levels and synaptosomal 5‐HT uptake were both decreased in a subregion‐specific manner, with the greatest decrease observed in the DG, a moderate decrease in the CA3, and the CA1 showed no apparent change. In addition, a reduction in tissue mass was detected in the DG following the CORT treatment. These data indicate that subregion‐specific decreases in hippocampal 5‐HTT protein expression and function are associated with endophenotypes of depression. © 2014 Wiley Periodicals, Inc.
Stress influences the development of depression, and depression is associated with structural and functional changes in the hippocampus. The current study sought to determine whether chronic corticosteroid (CORT) treatment influences serotonin transporter (5‐HTT) protein expression and function in the CA1, CA3, and dentate gyrus (DG) subregions of the hippocampus. Male CD‐1 mice were subcutaneously injected with CORT at a dose of 20 mg/kg once daily for 3 weeks. Behavioral state was assessed using sucrose preference, physical state of the coat, forced swimming test, and tail suspension test. We then determine 5‐HTT protein expression and synaptosomal 5‐HT uptake in the CA1, CA3 and DG subregions. CORT treatment induced anhedonia and behavioral despair, two core endophenotypes of clinical depression; 5‐HTT protein expression levels and synaptosomal 5‐HT uptake were both decreased in a subregion‐specific manner, with the greatest decrease observed in the DG, a moderate decrease in the CA3, and the CA1 showed no apparent change. In addition, a reduction in tissue mass was detected in the DG following the CORT treatment. These data indicate that subregion‐specific decreases in hippocampal 5‐HTT protein expression and function are associated with endophenotypes of depression. © 2014 Wiley Periodicals, Inc.
Stress influences the development of depression, and depression is associated with structural and functional changes in the hippocampus. The current study sought to determine whether chronic corticosteroid (CORT) treatment influences serotonin transporter (5-HTT) protein expression and function in the CA1, CA3, and dentate gyrus (DG) subregions of the hippocampus. Male CD-1 mice were subcutaneously injected with CORT at a dose of 20 mg/kg once daily for 3 weeks. Behavioral state was assessed using sucrose preference, physical state of the coat, forced swimming test, and tail suspension test. We then determine 5-HTT protein expression and synaptosomal 5-HT uptake in the CA1, CA3 and DG subregions. CORT treatment induced anhedonia and behavioral despair, two core endophenotypes of clinical depression; 5-HTT protein expression levels and synaptosomal 5-HT uptake were both decreased in a subregion-specific manner, with the greatest decrease observed in the DG, a moderate decrease in the CA3, and the CA1 showed no apparent change. In addition, a reduction in tissue mass was detected in the DG following the CORT treatment. These data indicate that subregion-specific decreases in hippocampal 5-HTT protein expression and function are associated with endophenotypes of depression. © 2014 Wiley Periodicals, Inc. [PUBLICATION ABSTRACT]
Author Tang, Man
He, Tao
Sun, Xiao
He, Xiao-Jing
Chen, Lei
Zhao, Shulei
Diao, Yao
Sang, Xiu-Bo
Meng, Qing-Yan
Lei, Jie-Yu
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  fullname: Meng, Qing-Yan
  organization: Department of Burns, The Northern Hospital, Shenyang, China
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  givenname: Shulei
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  fullname: Zhao, Shulei
  organization: Section of Integrative Biology, School of Biological Sciences, University of Texas, Texas, Austin
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Keywords corticosteroid
behavioral despair
hippocampus
synaptosomal 5-HT uptake
anhedonia
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PublicationDate April 2014
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  year: 2014
  text: April 2014
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PublicationTitle Hippocampus
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PublicationYear 2014
Publisher Blackwell Publishing Ltd
Wiley Subscription Services, Inc
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1977; 172
2002; 51
1968; 3
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2010; 206
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2005; 115
2006; 17
2000; 911
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2006; 7
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Snippet ABSTRACT Stress influences the development of depression, and depression is associated with structural and functional changes in the hippocampus. The current...
Stress influences the development of depression, and depression is associated with structural and functional changes in the hippocampus. The current study...
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SubjectTerms Adrenal Cortex Hormones
anhedonia
Anhedonia - physiology
Animals
behavioral despair
CA1 Region, Hippocampal - metabolism
CA3 Region, Hippocampal - metabolism
corticosteroid
Dentate Gyrus - metabolism
Dentate Gyrus - pathology
Depressive Disorder - metabolism
Depressive Disorder - pathology
Disease Models, Animal
Endophenotypes
hippocampus
Hippocampus - metabolism
Male
Mice
Mice, Inbred Strains
Organ Size
Random Allocation
Serotonin - metabolism
Serotonin Plasma Membrane Transport Proteins - metabolism
synaptosomal 5-HT uptake
Synaptosomes - metabolism
Title Subregion-specific decreases in hippocampal serotonin transporter protein expression and function associated with endophenotypes of depression
URI https://api.istex.fr/ark:/67375/WNG-BPC1ZSWK-9/fulltext.pdf
https://onlinelibrary.wiley.com/doi/abs/10.1002/hipo.22242
https://www.ncbi.nlm.nih.gov/pubmed/24436084
https://www.proquest.com/docview/1507759913
https://www.proquest.com/docview/1508417891
Volume 24
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