The Noradrenergic System of Aged GDNF Heterozygous Mice

• Published in: Cell transplantation Vol. 12; no. 3; pp. 291 - 303
• Main Authors: Zaman, V., Li, Z., Middaugh, L., Ramamoorthy, S., Rohrer, B., Nelson, M. E., Tomac, A. C., Hoffer, B. J., Gerhardt, G. A., Granholm, A. Ch
• Format: Journal Article
• Language: English
• Published: Los Angeles, CA SAGE Publications 01.04.2003; SAGE Publishing
• Subjects: Aging - physiology; Animals; Brain Chemistry; Brain Stem - metabolism; Cerebellum - cytology; Cerebellum - metabolism; Frontal Lobe - cytology; Frontal Lobe - metabolism; Glial Cell Line-Derived Neurotrophic Factor; Hippocampus - cytology; Hippocampus - metabolism; Locus Coeruleus - cytology; Locus Coeruleus - metabolism; Male; Mice; Mice, Inbred C57BL; Mice, Transgenic; Motor Activity - physiology; Nerve Growth Factors - genetics; Nerve Growth Factors - metabolism; Neurons - physiology; Norepinephrine - chemistry; Norepinephrine - metabolism; Norepinephrine Plasma Membrane Transport Proteins; Symporters - metabolism; Synaptosomes - chemistry; Synaptosomes - metabolism; Tyrosine 3-Monooxygenase - metabolism; Aging; Neurotrophic factors; Glial cell line-derived neurotrophic factor (GDNF); Noradrenergic system; Locus coeruleus

Glial cell line-derived neurotrophic factor (GDNF) is a trophic factor for noradrenergic (NE) neurons of the pontine nucleus locus coeruleus (LC). Decreased function of the LC-NE neurons has been found during normal aging and in neurodegenerative disorders. We have previously shown that GDNF partici...