Mitochondrial dysfunction and Parkinson disease: a Parkin-AMPK alliance in neuroprotection

• Published in: Annals of the New York Academy of Sciences Vol. 1350; no. 1; pp. 37 - 47
• Main Authors: Hang, Liting, Thundyil, John, Lim, Kah-Leong
• Format: Journal Article
• Language: English
• Published: United States Blackwell Publishing Ltd 01.09.2015; Wiley Subscription Services, Inc
• Subjects: AMP-Activated Protein Kinases - genetics; AMP-Activated Protein Kinases - metabolism; Animals; Biosynthesis; dopamine; Homeostasis; Humans; Kinases; LRRK2; Mitochondria - enzymology; Mitochondria - metabolism; Mitochondrial Diseases - etiology; Mitochondrial Turnover; mitophagy; Models, Biological; Mutation; neurodegeneration; Neurons - enzymology; Neurons - metabolism; Parkinson Disease - genetics; Parkinson Disease - metabolism; Parkinson Disease - physiopathology; Parkinson's disease; PGC-1α; PINK1; Protein Kinases - genetics; Protein Kinases - metabolism; Ubiquitin-Protein Ligases - genetics; Ubiquitin-Protein Ligases - metabolism; neurodegeneration; PINK1; mitophagy; PGC-1α; dopamine; LRRK2

Although a subject of intense research, the etiology of Parkinson disease (PD) remains poorly understood. However, a wide range of studies conducted over the past few decades have collectively implicated aberrant mitochondrial homeostasis as a key contributor to the development of PD. Particularly s...