Genistein inhibits differentiation of primary human adipocytes
Genistein, a major soy isoflavone, has been reported to exhibit antiadipogenic and proapoptotic potential in vivo and in vitro. It is also a phytoestrogen which has high affinity to estrogen receptor β. In this study, we determined the effect of genistein on adipogenesis and estrogen receptor (ER) α...
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Published in | The Journal of nutritional biochemistry Vol. 20; no. 2; pp. 140 - 148 |
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Main Authors | , , , , , |
Format | Journal Article |
Language | English |
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01.02.2009
New York, NY: Elsevier Science Elsevier |
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Abstract | Genistein, a major soy isoflavone, has been reported to exhibit antiadipogenic and proapoptotic potential in vivo and in vitro. It is also a phytoestrogen which has high affinity to estrogen receptor β. In this study, we determined the effect of genistein on adipogenesis and estrogen receptor (ER) α and β expression during differentiation in primary human preadipocytes. Genistein inhibited lipid accumulation in a dose-dependent manner at concentrations of 6.25 μM and higher, with 50 μM genistein inhibiting lipid accumulation almost completely. Low concentrations of genistein (3.25 μM) increased cell viability and higher concentrations (25 and 50 μM) decreased it by 16.48±1.35% (
P<.0001) and 50.68±1.34% (
P<.0001). Oil Red O staining was used to confirm the effects on lipid accumulation. The inhibition of lipid accumulation was associated with inhibition of glycerol-3-phosphate dehydrogenase activity and down-regulation of expression of adipocyte-specific genes, including peroxisome proliferator-activated receptor γ, CCAAT/enhancer binding protein α, glycerol-3-phosphate dehydrogenase, adipocyte fatty acid binding protein, fatty acid synthase, sterol regulatory element-binding protein 1, perilipin, leptin, lipoprotein lipase and hormone-sensitive lipase. These effects of genistein during the differentiation period were associated with down-regulation of
ERα and
ERβ expression. This study adds to the elucidation of the molecular pathways involved in the inhibition of adipogenesis by phytoestrogens. |
---|---|
AbstractList | Genistein, a major soy isoflavone, has been reported to exhibit antiadipogenic and proapoptotic potential in vivo and in vitro. It is also a phytoestrogen which has high affinity to estrogen receptor β. In this study, we determined the effect of genistein on adipogenesis and estrogen receptor (ER) α and β expression during differentiation in primary human preadipocytes. Genistein inhibited lipid accumulation in a dose-dependent manner at concentrations of 6.25 μM and higher, with 50 μM genistein inhibiting lipid accumulation almost completely. Low concentrations of genistein (3.25 μM) increased cell viability and higher concentrations (25 and 50 μM) decreased it by 16.48±1.35% (
P<.0001) and 50.68±1.34% (
P<.0001). Oil Red O staining was used to confirm the effects on lipid accumulation. The inhibition of lipid accumulation was associated with inhibition of glycerol-3-phosphate dehydrogenase activity and down-regulation of expression of adipocyte-specific genes, including peroxisome proliferator-activated receptor γ, CCAAT/enhancer binding protein α, glycerol-3-phosphate dehydrogenase, adipocyte fatty acid binding protein, fatty acid synthase, sterol regulatory element-binding protein 1, perilipin, leptin, lipoprotein lipase and hormone-sensitive lipase. These effects of genistein during the differentiation period were associated with down-regulation of
ERα and
ERβ expression. This study adds to the elucidation of the molecular pathways involved in the inhibition of adipogenesis by phytoestrogens. Genistein, a major soy isoflavone, has been reported to exhibit antiadipogenic and proapoptotic potential in vivo and in vitro. It is also a phytoestrogen which has high affinity to estrogen receptor β. In this study, we determined the effect of genistein on adipogenesis and estrogen receptor (ER) α and β expression during differentiation in primary human preadipocytes. Genistein inhibited lipid accumulation in a dose-dependent manner at concentrations of 6.25 μM and higher, with 50 μM genistein inhibiting lipid accumulation almost completely. Low concentrations of genistein (3.25 μM) increased cell viability and higher concentrations (25 and 50 μM) decreased it by 16.48±1.35% (P<.0001) and 50.68±1.34% (P<.0001). Oil Red O staining was used to confirm the effects on lipid accumulation. The inhibition of lipid accumulation was associated with inhibition of glycerol-3-phosphate dehydrogenase activity and down-regulation of expression of adipocyte-specific genes, including peroxisome proliferator-activated receptor γ, CCAAT/enhancer binding protein α, glycerol-3-phosphate dehydrogenase, adipocyte fatty acid binding protein, fatty acid synthase, sterol regulatory element-binding protein 1, perilipin, leptin, lipoprotein lipase and hormone-sensitive lipase. These effects of genistein during the differentiation period were associated with down-regulation of ERα and ERβ expression. This study adds to the elucidation of the molecular pathways involved in the inhibition of adipogenesis by phytoestrogens. Genistein, a major soy isoflavone, has been reported to exhibit antiadipogenic and proapoptotic potential in vivo and in vitro. It is also a phytoestrogen which has high affinity to estrogen receptor beta. In this study, we determined the effect of genistein on adipogenesis and estrogen receptor (ER) alpha and beta expression during differentiation in primary human preadipocytes. Genistein inhibited lipid accumulation in a dose-dependent manner at concentrations of 6.25 microM and higher, with 50 microM genistein inhibiting lipid accumulation almost completely. Low concentrations of genistein (3.25 microM) increased cell viability and higher concentrations (25 and 50 microM) decreased it by 16.48+/-1.35% (P<.0001) and 50.68+/-1.34% (P<.0001). Oil Red O staining was used to confirm the effects on lipid accumulation. The inhibition of lipid accumulation was associated with inhibition of glycerol-3-phosphate dehydrogenase activity and down-regulation of expression of adipocyte-specific genes, including peroxisome proliferator-activated receptor gamma, CCAAT/enhancer binding protein alpha, glycerol-3-phosphate dehydrogenase, adipocyte fatty acid binding protein, fatty acid synthase, sterol regulatory element-binding protein 1, perilipin, leptin, lipoprotein lipase and hormone-sensitive lipase. These effects of genistein during the differentiation period were associated with down-regulation of ERalpha and ERbeta expression. This study adds to the elucidation of the molecular pathways involved in the inhibition of adipogenesis by phytoestrogens. Genistein, a major soy isoflavone, has been reported to exhibit antiadipogenic and proapoptotic potential in vivo and in vitro. It is also a phytoestrogen which has high affinity to estrogen receptor beta. In this study, we determined the effect of genistein on adipogenesis and estrogen receptor (ER) alpha and beta expression during differentiation in primary human preadipocytes. Genistein inhibited lipid accumulation in a dose-dependent manner at concentrations of 6.25 microM and higher, with 50 microM genistein inhibiting lipid accumulation almost completely. Low concentrations of genistein (3.25 microM) increased cell viability and higher concentrations (25 and 50 microM) decreased it by 16.48+/-1.35% (P<.0001) and 50.68+/-1.34% (P<.0001). Oil Red O staining was used to confirm the effects on lipid accumulation. The inhibition of lipid accumulation was associated with inhibition of glycerol-3-phosphate dehydrogenase activity and down-regulation of expression of adipocyte-specific genes, including peroxisome proliferator-activated receptor gamma, CCAAT/enhancer binding protein alpha, glycerol-3-phosphate dehydrogenase, adipocyte fatty acid binding protein, fatty acid synthase, sterol regulatory element-binding protein 1, perilipin, leptin, lipoprotein lipase and hormone-sensitive lipase. These effects of genistein during the differentiation period were associated with down-regulation of ERalpha and ERbeta expression. This study adds to the elucidation of the molecular pathways involved in the inhibition of adipogenesis by phytoestrogens. |
Author | Baile, Clifton A. Park, Hea Jin Hausman, Dorothy B. Ambati, Suresh Della-Fera, Mary Anne Rayalam, Srujana |
Author_xml | – sequence: 1 givenname: Hea Jin surname: Park fullname: Park, Hea Jin organization: Department of Animal & Dairy Science, University of Georgia, Athens, GA 30602-2771, USA – sequence: 2 givenname: Mary Anne surname: Della-Fera fullname: Della-Fera, Mary Anne organization: Department of Animal & Dairy Science, University of Georgia, Athens, GA 30602-2771, USA – sequence: 3 givenname: Dorothy B. surname: Hausman fullname: Hausman, Dorothy B. organization: Department of Foods and Nutrition, University of Georgia, Athens, GA 30602-2771, USA – sequence: 4 givenname: Srujana surname: Rayalam fullname: Rayalam, Srujana organization: Department of Animal & Dairy Science, University of Georgia, Athens, GA 30602-2771, USA – sequence: 5 givenname: Suresh surname: Ambati fullname: Ambati, Suresh organization: Department of Animal & Dairy Science, University of Georgia, Athens, GA 30602-2771, USA – sequence: 6 givenname: Clifton A. surname: Baile fullname: Baile, Clifton A. email: cbaile@uga.edu organization: Department of Animal & Dairy Science, University of Georgia, Athens, GA 30602-2771, USA |
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Keywords | Phytoestrogen Estrogen receptor GPDH activity Gene expression Adipogenesis Human Isoflavone Adipocyte Genistein Vertebrata Mammalia Differentiation Hormonal receptor |
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Snippet | Genistein, a major soy isoflavone, has been reported to exhibit antiadipogenic and proapoptotic potential in vivo and in vitro. It is also a phytoestrogen... |
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SubjectTerms | adipocytes Adipocytes - cytology Adipocytes - drug effects Adipocytes - enzymology Adipogenesis adipose tissue Biological and medical sciences cell culture Cell Differentiation - drug effects cell proliferation Cell Survival - drug effects Cryopreservation DNA Probes Estrogen receptor fatty acid-binding proteins fatty-acid synthase Feeding. Feeding behavior Fundamental and applied biological sciences. Psychology Gene expression gene expression regulation genistein Genistein - pharmacology glycerol-3-phosphate dehydrogenase (NAD) Glycerolphosphate Dehydrogenase - metabolism GPDH activity hormone receptors hormone-sensitive lipase Humans Kinetics leptin lipogenesis lipoprotein lipase nutrition-genotype interaction obesity perilipin peroxisomes Phytoestrogen plant estrogens PPAR gamma - genetics Reverse Transcriptase Polymerase Chain Reaction RNA - drug effects RNA - genetics RNA, Ribosomal, 18S - drug effects RNA, Ribosomal, 18S - genetics soy protein soybean products sterol regulatory element-binding protein 1 Vertebrates: anatomy and physiology, studies on body, several organs or systems weight control weight loss |
Title | Genistein inhibits differentiation of primary human adipocytes |
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