Select Flavonoids and Whole Juice From Purple Grapes Inhibit Platelet Function and Enhance Nitric Oxide Release

• Published in: Circulation (New York, N.Y.) Vol. 103; no. 23; pp. 2792 - 2798
• Main Authors: Freedman, Jane E., Parker, Crawford, Li, Liqing, Perlman, Jacob A., Frei, Balz, Ivanov, Vadim, Deak, Leslie R., Iafrati, Mark D., Folts, John D.
• Format: Journal Article
• Language: English
• Published: Hagerstown, MD Lippincott Williams & Wilkins 12.06.2001; American Heart Association, Inc
• Subjects: Adult; Antioxidants - metabolism; Biological and medical sciences; Blood Platelets - drug effects; Blood Platelets - metabolism; Cell Line; Cell Separation; Dietary Supplements; Dose-Response Relationship, Drug; Female; Flavonoids - chemistry; Flavonoids - pharmacology; Fruit - chemistry; General and cellular metabolism. Vitamins; Humans; Male; Medical sciences; Megakaryocytes - drug effects; Megakaryocytes - enzymology; Middle Aged; Nitric Oxide - metabolism; Nitric Oxide Synthase - metabolism; Nitric Oxide Synthase Type III; Pharmacology. Drug treatments; Platelet Aggregation - drug effects; Platelet Function Tests; Protein Kinase C - metabolism; Rosales; Superoxides - metabolism; Vitamin E - blood; Aggregation; Human; Platelet; Nitric oxide; Grape; Antioxidant; Flavonoid; Fruit juice; Biological activity

Background —Moderate red wine consumption is inversely associated with coronary ischemia, and both red wine and purple grape juice (PGJ) contain flavonoids with antioxidant and antiplatelet properties believed to be protective against cardiovascular events. Acute cardiac events are also associated w...