Cellular iron deposition patterns predict clinical subtypes of multiple system atrophy

• Published in: Neurobiology of disease Vol. 197; p. 106535
• Main Authors: Lee, Seojin, Martinez-Valbuena, Ivan, Lang, Anthony E., Kovacs, Gabor G.
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01.07.2024; Elsevier
• Subjects: Aged; Aged, 80 and over; Alpha-synuclein; alpha-Synuclein - metabolism; Atypical parkinsonism; Brain - metabolism; Brain - pathology; Female; Humans; Iron; Iron - metabolism; Male; Microglia; Middle Aged; Multiple system atrophy; Multiple System Atrophy - metabolism; Multiple System Atrophy - pathology; Neurodegeneration; Oligodendroglia - metabolism; Oligodendroglia - pathology; Multiple system atrophy; Iron; Atypical parkinsonism; Neurodegeneration; Alpha-synuclein; Microglia

Multiple system atrophy (MSA) is a primary oligodendroglial synucleinopathy, characterized by elevated iron burden in early-affected subcortical nuclei. Although neurotoxic effects of brain iron deposition and its relationship with α-synuclein pathology have been demonstrated, the exact role of iron...