A feedback loop between heterochromatin and the nucleopore complex controls germ-cell-to-oocyte transition during Drosophila oogenesis

• Published in: Developmental cell Vol. 58; no. 22; pp. 2580 - 2596.e6
• Main Authors: Sarkar, Kahini, Kotb, Noor M., Lemus, Alex, Martin, Elliot T., McCarthy, Alicia, Camacho, Justin, Iqbal, Ayman, Valm, Alex M., Sammons, Morgan A., Rangan, Prashanth
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 20.11.2023
• Subjects: Animals; differentiation; Drosophila - metabolism; Drosophila Proteins - genetics; Drosophila Proteins - metabolism; Feedback; germ cells; Germ Cells - metabolism; germ line; heterochromatin; Heterochromatin - metabolism; Humans; NPC; nucleopore complex; oocyte; Oocytes - metabolism; Oogenesis - genetics; SETDB1; germ line; NPC; nucleopore complex; oocyte; differentiation; SETDB1; germ cells; heterochromatin
• ISSN: 1534-5807; 1878-1551; 1878-1551
• DOI: 10.1016/j.devcel.2023.08.014

Germ cells differentiate into oocytes that launch the next generation upon fertilization. How the highly specialized oocyte acquires this distinct cell fate is poorly understood. During Drosophila oogenesis, H3K9me3 histone methyltransferase SETDB1 translocates from the cytoplasm to the nucleus of g...