The Effect of a High-Fat Breakfast on the Pharmacokinetics of Moxidectin in Healthy Male Subjects: A Randomized Phase I Trial
The objective of this study was to assess the effect of a high-fat meal on the pharmacokinetics of moxidectin. Healthy male subjects were randomized to receive single oral 8 mg doses of moxidectin after an overnight fast or high-fat breakfast. In fasted subjects ( N = 27), mean [SD] parameters were...
Saved in:
| Published in | The American journal of tropical medicine and hygiene Vol. 86; no. 1; pp. 122 - 125 |
|---|---|
| Main Authors | , , , , , , , |
| Format | Journal Article |
| Language | English |
| Published |
Deerfield, IL
American Society of Tropical Medecine and Hygiene
01.01.2012
The American Society of Tropical Medicine and Hygiene |
| Subjects | |
| Online Access | Get full text |
| ISSN | 0002-9637 1476-1645 1476-1645 |
| DOI | 10.4269/ajtmh.2012.11-0415 |
Cover
| Abstract | The objective of this study was to assess the effect of a high-fat meal on the pharmacokinetics of moxidectin. Healthy male subjects were randomized to receive single oral 8 mg doses of moxidectin after an overnight fast or high-fat breakfast. In fasted subjects (
N
= 27), mean [SD] parameters were C
max
: 58.9 [12.5] ng/mL; t
max
: 3.7 [1.5] h; area under concentration-time curve (AUC): 3,387 [1,328] ng/h/mL; Vλ
z
/F: 2,829 [1,267] L; CL/F: 2.76 [1.28] L/h; and t
½
: 784 [347] h. Compared with fasted subjects, fed subjects (
N
= 27) exhibited a 34% increase in C
max
, delay in t
max
to 5.3 [2.1] h, 44% increase in AUC, 40% decrease in Vλ
z
/F, and a 35% decrease in CL/F. There was no significant change in t
½
. The changes are consistent with an increase in moxidectin bioavailability following administration with food. There were no clinically relevant changes in vital signs, laboratory tests, or electrocardiograms. |
|---|---|
| AbstractList | The objective of this study was to assess the effect of a high-fat meal on the pharmacokinetics of moxidectin. Healthy male subjects were randomized to receive single oral 8 mg doses of moxidectin after an overnight fast or high-fat breakfast. In fasted subjects (N = 27), mean [SD] parameters were C sub(max): 58.9 [12.5] ng/mL; t sub(max): 3.7 [1.5] h; area under concentration-time curve (AUC): 3,387 [1,328] ng/h/mL; lambda sub(z)/F: 2,829 [1,267] L; CL/F: 2.76 [1.28] L/h; and t sub(1/2): 784 [347] h. Compared with fasted subjects, fed subjects (N = 27) exhibited a 34% increase in C sub(max), delay in t sub(max) to 5.3 [2.1] h, 44% increase in AUC, 40% decrease in V lambda sub(z)/F, and a 35% decrease in CL/F. There was no significant change in t sub(1/2). The changes are consistent with an increase in moxidectin bioavailability following administration with food. There were no clinically relevant changes in vital signs, laboratory tests, or electrocardiograms. The objective of this study was to assess the effect of a high-fat meal on the pharmacokinetics of moxidectin. Healthy male subjects were randomized to receive single oral 8 mg doses of moxidectin after an overnight fast or high-fat breakfast. In fasted subjects (N = 27), mean [SD] parameters were C(max): 58.9 [12.5] ng/mL; t(max): 3.7 [1.5] h; area under concentration-time curve (AUC): 3,387 [1,328] ng/h/mL; Vλ(z)/F: 2,829 [1,267] L; CL/F: 2.76 [1.28] L/h; and t(1/2): 784 [347] h. Compared with fasted subjects, fed subjects (N = 27) exhibited a 34% increase in C(max), delay in t(max) to 5.3 [2.1] h, 44% increase in AUC, 40% decrease in Vλ(z)/F, and a 35% decrease in CL/F. There was no significant change in t(1/2). The changes are consistent with an increase in moxidectin bioavailability following administration with food. There were no clinically relevant changes in vital signs, laboratory tests, or electrocardiograms. The objective of this study was to assess the effect of a high-fat meal on the pharmacokinetics of moxidectin. Healthy male subjects were randomized to receive single oral 8 mg doses of moxidectin after an overnight fast or high-fat breakfast. In fasted subjects ( N = 27), mean [SD] parameters were C max : 58.9 [12.5] ng/mL; t max : 3.7 [1.5] h; area under concentration-time curve (AUC): 3,387 [1,328] ng/h/mL; Vλ z /F: 2,829 [1,267] L; CL/F: 2.76 [1.28] L/h; and t ½ : 784 [347] h. Compared with fasted subjects, fed subjects ( N = 27) exhibited a 34% increase in C max , delay in t max to 5.3 [2.1] h, 44% increase in AUC, 40% decrease in Vλ z /F, and a 35% decrease in CL/F. There was no significant change in t ½ . The changes are consistent with an increase in moxidectin bioavailability following administration with food. There were no clinically relevant changes in vital signs, laboratory tests, or electrocardiograms. The objective of this study was to assess the effect of a high-fat meal on the pharmacokinetics of moxidectin. Healthy male subjects were randomized to receive single oral 8 mg doses of moxidectin after an overnight fast or high-fat breakfast. In fasted subjects (N = 27), mean [SD] parameters were C(max): 58.9 [12.5] ng/mL; t(max): 3.7 [1.5] h; area under concentration-time curve (AUC): 3,387 [1,328] ng/h/mL; Vλ(z)/F: 2,829 [1,267] L; CL/F: 2.76 [1.28] L/h; and t(1/2): 784 [347] h. Compared with fasted subjects, fed subjects (N = 27) exhibited a 34% increase in C(max), delay in t(max) to 5.3 [2.1] h, 44% increase in AUC, 40% decrease in Vλ(z)/F, and a 35% decrease in CL/F. There was no significant change in t(1/2). The changes are consistent with an increase in moxidectin bioavailability following administration with food. There were no clinically relevant changes in vital signs, laboratory tests, or electrocardiograms.The objective of this study was to assess the effect of a high-fat meal on the pharmacokinetics of moxidectin. Healthy male subjects were randomized to receive single oral 8 mg doses of moxidectin after an overnight fast or high-fat breakfast. In fasted subjects (N = 27), mean [SD] parameters were C(max): 58.9 [12.5] ng/mL; t(max): 3.7 [1.5] h; area under concentration-time curve (AUC): 3,387 [1,328] ng/h/mL; Vλ(z)/F: 2,829 [1,267] L; CL/F: 2.76 [1.28] L/h; and t(1/2): 784 [347] h. Compared with fasted subjects, fed subjects (N = 27) exhibited a 34% increase in C(max), delay in t(max) to 5.3 [2.1] h, 44% increase in AUC, 40% decrease in Vλ(z)/F, and a 35% decrease in CL/F. There was no significant change in t(1/2). The changes are consistent with an increase in moxidectin bioavailability following administration with food. There were no clinically relevant changes in vital signs, laboratory tests, or electrocardiograms. |
| Author | Korth-Bradley, Joan M. Matschke, Kyle Gourley, Ian Fleckenstein, Lawrence Parks, Virginia Cailleux, Karine Chalon, Stephan Fitoussi, Serge |
| AuthorAffiliation | Pfizer, Inc., Collegeville, Pennsylvania; Pfizer Global Research and Development, Paris, France; MEDISCIS Poitiers (legal name Larime S.A.), Poitiers, France; College of Pharmacy, University of Iowa, Iowa City, Iowa |
| AuthorAffiliation_xml | – name: Pfizer, Inc., Collegeville, Pennsylvania; Pfizer Global Research and Development, Paris, France; MEDISCIS Poitiers (legal name Larime S.A.), Poitiers, France; College of Pharmacy, University of Iowa, Iowa City, Iowa |
| Author_xml | – sequence: 1 givenname: Joan M. surname: Korth-Bradley fullname: Korth-Bradley, Joan M. – sequence: 2 givenname: Virginia surname: Parks fullname: Parks, Virginia – sequence: 3 givenname: Stephan surname: Chalon fullname: Chalon, Stephan – sequence: 4 givenname: Ian surname: Gourley fullname: Gourley, Ian – sequence: 5 givenname: Kyle surname: Matschke fullname: Matschke, Kyle – sequence: 6 givenname: Karine surname: Cailleux fullname: Cailleux, Karine – sequence: 7 givenname: Serge surname: Fitoussi fullname: Fitoussi, Serge – sequence: 8 givenname: Lawrence surname: Fleckenstein fullname: Fleckenstein, Lawrence |
| BackLink | http://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=26066695$$DView record in Pascal Francis https://www.ncbi.nlm.nih.gov/pubmed/22232462$$D View this record in MEDLINE/PubMed |
| BookMark | eNp9kk9v1DAQxS1URLeFL8AB-YLgksV2HCfhgFSqlq3UCgTL2Zo4k8bbxC6xF1EkvjsO3fLvUMmSJc_vvRnb74DsOe-QkKecLaVQ9SvYxLFfCsbFkvOMSV48IAsuS5VxJYs9smCMiaxWeblPDkLYMMYrwfkjsi-EyIVUYkF-rHukJ12HJlLfUaAre9lnpxDp2wnhqoOQzh2NifrQwzSC8VfWYbQmzPyF_2bbpLWOprVCGGJ_Qy9gQPpp22xSJbymR_QjuNaP9ju2s0tAekbXk4XhMXnYwRDwyW4_JJ9PT9bHq-z8_buz46PzzEglY9aWXVnUFRYSK8kNdKZhoLBmiEzlKI0qUFRKCNmCaLkSNatKVvCci0Y2UuSH5M2t7_W2GbE16OIEg76e7AjTjfZg9b8VZ3t96b_q9EolFywZvNgZTP7LFkPUow0GhwEc-m3QNS_ysi6KmXx5L8kZl5yxqioS-uzvqX6Pc_c7CXi-AyAYGLoJnLHhD6eYUqqejapbzkw-hAk7bWyEaP18GTuknnoOjP4VGD0HRnOu58AkqfhPeud-j-gnwQbDzA |
| CODEN | AJTHAB |
| CitedBy_id | crossref_primary_10_1371_journal_pntd_0011633 crossref_primary_10_1007_s40262_020_00871_5 crossref_primary_10_1016_j_jchromb_2021_122556 crossref_primary_10_1371_journal_pntd_0007591 crossref_primary_10_1186_s13071_022_05581_4 crossref_primary_10_1371_journal_pntd_0010005 crossref_primary_10_1016_j_pt_2023_01_009 crossref_primary_10_1016_S0140_6736_17_32844_1 crossref_primary_10_1186_s13071_023_06087_3 crossref_primary_10_1097_QCO_0b013e32835e1d57 crossref_primary_10_1016_S1473_3099_18_30233_0 crossref_primary_10_1517_17425255_2013_832200 crossref_primary_10_1016_j_ijpddr_2023_02_004 crossref_primary_10_1371_journal_pntd_0010079 crossref_primary_10_1371_journal_pntd_0011567 crossref_primary_10_1080_14787210_2020_1792772 crossref_primary_10_1007_s00436_016_5062_x crossref_primary_10_12688_gatesopenres_13299_1 crossref_primary_10_12688_gatesopenres_13299_2 crossref_primary_10_1111_cts_12583 crossref_primary_10_3390_covid2010005 crossref_primary_10_1371_journal_pntd_0002953 crossref_primary_10_1016_j_ijpddr_2016_04_002 crossref_primary_10_1002_cpdd_81 crossref_primary_10_1371_journal_pntd_0001883 |
| ContentType | Journal Article |
| Copyright | 2015 INIST-CNRS The American Society of Tropical Medicine and Hygiene 2012 |
| Copyright_xml | – notice: 2015 INIST-CNRS – notice: The American Society of Tropical Medicine and Hygiene 2012 |
| DBID | AAYXX CITATION IQODW CGR CUY CVF ECM EIF NPM 7QL 7T2 C1K M7N 7X8 5PM |
| DOI | 10.4269/ajtmh.2012.11-0415 |
| DatabaseName | CrossRef Pascal-Francis Medline MEDLINE MEDLINE (Ovid) MEDLINE MEDLINE PubMed Bacteriology Abstracts (Microbiology B) Health and Safety Science Abstracts (Full archive) Environmental Sciences and Pollution Management Algology Mycology and Protozoology Abstracts (Microbiology C) MEDLINE - Academic PubMed Central (Full Participant titles) |
| DatabaseTitle | CrossRef MEDLINE Medline Complete MEDLINE with Full Text PubMed MEDLINE (Ovid) Health & Safety Science Abstracts Bacteriology Abstracts (Microbiology B) Algology Mycology and Protozoology Abstracts (Microbiology C) Environmental Sciences and Pollution Management MEDLINE - Academic |
| DatabaseTitleList | Health & Safety Science Abstracts MEDLINE CrossRef MEDLINE - Academic |
| Database_xml | – sequence: 1 dbid: NPM name: PubMed url: https://proxy.k.utb.cz/login?url=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed sourceTypes: Index Database – sequence: 2 dbid: EIF name: MEDLINE url: https://proxy.k.utb.cz/login?url=https://www.webofscience.com/wos/medline/basic-search sourceTypes: Index Database |
| DeliveryMethod | fulltext_linktorsrc |
| Discipline | Medicine |
| DocumentTitleAlternate | KORTH-BRADLEY AND OTHERS |
| EISSN | 1476-1645 |
| EndPage | 125 |
| ExternalDocumentID | PMC3247120 22232462 26066695 10_4269_ajtmh_2012_11_0415 |
| Genre | Clinical Trial, Phase I Randomized Controlled Trial Research Support, Non-U.S. Gov't Journal Article |
| GroupedDBID | --- 23M 2WC 34G 36B 53G 5GY 5RE 5VS 6J9 AAYXX ABCQX ABPPZ ABTNK ACGFO ADBBV ADTPD AENEX AIAGR ALMA_UNASSIGNED_HOLDINGS AOIJS BAWUL BTFSW CITATION DIK E3Z EBD EBS EJD EMB EMOBN F5P GX1 HYE K-O KQ8 L7B MV1 OK1 P2P PQQKQ RHI RPM SV3 TR2 TST UPT W8F WH7 WOQ WOW ~KM .55 .GJ 1CY 3O- AFFNX AGCDD AI. H13 IQODW NEJ OHT VH1 X7M XOL ZGI ZKB ZXP CGR CUY CVF ECM EIF NPM 7QL 7T2 C1K M7N 7X8 5PM |
| ID | FETCH-LOGICAL-c464t-d7f7598e54e841cafcb0a6e90ee063e4c65e286224da2d1629087051312b4b423 |
| ISSN | 0002-9637 1476-1645 |
| IngestDate | Thu Aug 21 17:36:11 EDT 2025 Fri Jul 11 11:33:49 EDT 2025 Fri Jul 11 04:01:56 EDT 2025 Thu Apr 03 07:10:31 EDT 2025 Wed Apr 02 07:22:14 EDT 2025 Thu Apr 24 23:07:28 EDT 2025 Tue Jul 01 02:34:39 EDT 2025 |
| IsDoiOpenAccess | true |
| IsOpenAccess | true |
| IsPeerReviewed | true |
| IsScholarly | true |
| Issue | 1 |
| Keywords | Human Healthy subject Phase I trial Fat Parasiticide Male Tropical medicine Moxidectin Pharmacokinetics |
| Language | English |
| License | CC BY 4.0 Freely available online through the American Journal of Tropical Medicine and Hygiene Open Access option. |
| LinkModel | OpenURL |
| MergedId | FETCHMERGED-LOGICAL-c464t-d7f7598e54e841cafcb0a6e90ee063e4c65e286224da2d1629087051312b4b423 |
| Notes | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 ObjectType-Undefined-3 |
| OpenAccessLink | https://pubmed.ncbi.nlm.nih.gov/PMC3247120 |
| PMID | 22232462 |
| PQID | 1014100885 |
| PQPubID | 23462 |
| PageCount | 4 |
| ParticipantIDs | pubmedcentral_primary_oai_pubmedcentral_nih_gov_3247120 proquest_miscellaneous_915379550 proquest_miscellaneous_1014100885 pubmed_primary_22232462 pascalfrancis_primary_26066695 crossref_citationtrail_10_4269_ajtmh_2012_11_0415 crossref_primary_10_4269_ajtmh_2012_11_0415 |
| ProviderPackageCode | CITATION AAYXX |
| PublicationCentury | 2000 |
| PublicationDate | 2012-01-01 2012 2012-Jan 20120101 |
| PublicationDateYYYYMMDD | 2012-01-01 |
| PublicationDate_xml | – month: 01 year: 2012 text: 2012-01-01 day: 01 |
| PublicationDecade | 2010 |
| PublicationPlace | Deerfield, IL |
| PublicationPlace_xml | – name: Deerfield, IL – name: United States |
| PublicationTitle | The American journal of tropical medicine and hygiene |
| PublicationTitleAlternate | Am J Trop Med Hyg |
| PublicationYear | 2012 |
| Publisher | American Society of Tropical Medecine and Hygiene The American Society of Tropical Medicine and Hygiene |
| Publisher_xml | – name: American Society of Tropical Medecine and Hygiene – name: The American Society of Tropical Medicine and Hygiene |
| References | Chen (R12) 2002; 29 Wu (R10) 2005; 22 APOC (R1) 2005 Gershkovich (R11) 2007; 32 Forrester (R6) 2002; 63 World Health Organization (R2) 2010 Cotreau (R5) 2003; 43 Zulalian (R8) 1994; 42 Plaisier (R4) 1991; 48 Cully (R7) 1994; 371 Parks (R9) 2004; 31 Basáñez (R3) 1999; 354 |
| References_xml | – year: 2010 ident: R2 – volume: 48 start-page: 271 year: 1991 ident: R4 article-title: The reproductive lifespan of Onchocerca volvulus in West African savanna – volume: 32 start-page: 24 year: 2007 ident: R11 article-title: Effect of a high-fat meal on absorption and disposition of lipophilic compounds: the importance of degree of association with triglyceride-rich lipoproteins – volume: 29 start-page: 917 year: 2002 ident: R12 article-title: Liquid chromatographic assay of moxidectin in human plasma for application to pharmacokinetic studies – volume: 371 start-page: 707 year: 1994 ident: R7 article-title: Cloning of an avermectin-sensitive glutamate-gated chloride channel from Caenorhabditis elegans – volume: 22 start-page: 11 year: 2005 ident: R10 article-title: Predicting drug disposition via application of BCS: transport/absorption/elimination interplay and development of a biopharmaceutics drug disposition classification system – volume: 31 start-page: 128 year: 2004 ident: R9 article-title: Relative bioavailability of liquid and tablet formulations of the antiparasitic moxidectin – volume: 43 start-page: 1108 year: 2003 ident: R5 article-title: The antiparasitic moxidectin: safety, tolerability, and pharmacokinetics in humans – year: 2005 ident: R1 – volume: 42 start-page: 381 year: 1994 ident: R8 article-title: Absorption, tissue distribution, metabolism, and excretion of moxidectin in cattle – volume: 354 start-page: 809 year: 1999 ident: R3 article-title: Population biology of human onchocerciasis – volume: 63 start-page: 1061 year: 2002 ident: R6 article-title: A glutamate-gated chloride channel subunit from Haemonchus contortus: expression in a mammalian cell line, ligand binding, and modulation of anthelmintic binding by glutamate |
| SSID | ssj0018211 |
| Score | 2.1640496 |
| Snippet | The objective of this study was to assess the effect of a high-fat meal on the pharmacokinetics of moxidectin. Healthy male subjects were randomized to receive... |
| SourceID | pubmedcentral proquest pubmed pascalfrancis crossref |
| SourceType | Open Access Repository Aggregation Database Index Database Enrichment Source |
| StartPage | 122 |
| SubjectTerms | Administration, Oral Adult Antibiotics. Antiinfectious agents. Antiparasitic agents Antinematodal Agents - administration & dosage Antinematodal Agents - pharmacokinetics Antiparasitic agents Area Under Curve Biological and medical sciences Biological Availability Dietary Fats - administration & dosage Dietary Fats - pharmacology Fasting Food-Drug Interactions Humans Infectious diseases Macrolides - administration & dosage Macrolides - pharmacokinetics Male Medical sciences Middle Aged Pharmacology. Drug treatments Young Adult |
| Title | The Effect of a High-Fat Breakfast on the Pharmacokinetics of Moxidectin in Healthy Male Subjects: A Randomized Phase I Trial |
| URI | https://www.ncbi.nlm.nih.gov/pubmed/22232462 https://www.proquest.com/docview/1014100885 https://www.proquest.com/docview/915379550 https://pubmed.ncbi.nlm.nih.gov/PMC3247120 |
| Volume | 86 |
| hasFullText | 1 |
| inHoldings | 1 |
| isFullTextHit | |
| isPrint | |
| link | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV1bb9MwFLbKkBASQlxHuUxG4q3KqD0naXgrl61jdENVh_ZW2Ym9lbFkalOJTeLv8js4x86tZVylKqpSJ3Fyvh6fz_7OCSEvYBDQhinjJVIaT3Dpe5ESsRdEXBmtFIsTTBQe7geDQ_H-yD9qtb43VEuLXG3Gl1fmlfyPVWEf2BWzZP_BstVJYQd8B_vCFiwM27-2cVF-2KY5omjD27aUX8tTI-d5sRbQ-VhUqD6FoNIWZkblS_Z1mqC_s2JHl4900RlKVBcuFM7PzF3e-kimSXY2vYTYFM4z153dzhjvrhnYjusMlbRZjiKfZecWB-Uivl2tOLk4BpdSYWrvYDQeeK9H_bcQLrs5fVxDqtx2f7RnFYafprPjaTqtxUWD_oeD_UqsVgN95-BwVJxqt9hbzGywmgFX3S2Vq9DdcdndoYZHU3Z30Ohu7eHBqYRND18U224i2blr5nKii5GfuRTs1UEFk31xxPycn-HqFeObOKssXBbqcgXvlZG10jtySxMj_xq5zsOQofR056iSIgHFY6ykadh3l9yF133581WXAqhb53IOD8W4l7BcxZJWxb6N6Gl8h9wuaA_tOwzfJS2d3iM3hgUm7pNvgB_qoEwzQyUtoUwrKNMspQBlugplbF9DmcKngDJFKNMSyq9on9ZAphbIdJdaID8gh9vvxm8GXvFmEC8Wgci9JDShH_W0L3RPsFiaWHVloKOu1hByaxEHvubA1blIJE9YwKMujEs-22JcCQUM4iFZS7NUPyJUAbuMjDBboeSix1VPB7IXcbPFE4NsoU1Y-bgncVE2H9_e8mUC9BlNNLEmmqCJgE5P0ERt0qmOOXdFY37bemPJitUhJWra5Hlp1gk4f1zRk6nOFnPUZwqsztWDNvQXbSKIacLI97ttsu6QUF-AI58KeJuESxipGmDt-eVf0umJrUEPx4WMdx__qe9PyE28Vzdp-ZSs5bOFfgZhfK427H_gB-QJ9h0 |
| linkProvider | Geneva Foundation for Medical Education and Research |
| openUrl | ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=The+Effect+of+a+High-Fat+Breakfast+on+the+Pharmacokinetics+of+Moxidectin+in+Healthy+Male+Subjects%3A+A+Randomized+Phase+I+Trial&rft.jtitle=The+American+journal+of+tropical+medicine+and+hygiene&rft.au=KORTH-BRADLEY%2C+Joan+M&rft.au=PARKS%2C+Virginia&rft.au=CHALON%2C+Stephan&rft.au=GOURLEY%2C+Ian&rft.date=2012&rft.pub=American+Society+of+Tropical+Medecine+and+Hygiene&rft.issn=0002-9637&rft.volume=86&rft.issue=1&rft.spage=122&rft.epage=125&rft_id=info:doi/10.4269%2Fajtmh.2012.11-0415&rft.externalDBID=n%2Fa&rft.externalDocID=26066695 |
| thumbnail_l | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=0002-9637&client=summon |
| thumbnail_m | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=0002-9637&client=summon |
| thumbnail_s | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=0002-9637&client=summon |