Tumor Expression of Cyclin-Dependent Kinase 5 (Cdk5) Is a Prognostic Biomarker and Predicts Outcome of Oxaliplatin-Treated Metastatic Colorectal Cancer Patients

• Published in: Cancers Vol. 11; no. 10; p. 1540
• Main Authors: Ruiz de Porras, Vicenç, Bystrup, Sara, Cabrero-de las Heras, Sara, Musulén, Eva, Palomero, Luis, Alonso, Maria Henar, Nieto, Rocio, Arango, Diego, Moreno, Víctor, Queralt, Cristina, Manzano, José Luis, Layos, Laura, Bugés, Cristina, Martinez-Balibrea, Eva
• Format: Journal Article
• Language: English
• Published: Basel MDPI AG 11.10.2019; MDPI
• Subjects: Biomarkers; Cell adhesion & migration; Cell cycle; Colorectal cancer; Colorectal carcinoma; Copy number; Cyclin-dependent kinase 5; cyclin-dependent kinase 5 (cdk5); Cyclin-dependent kinases; Kinases; Metastases; Metastasis; Motility; Nervous system; Oxaliplatin; Phosphorylation; Prognosis; prognostic and predictive biomarker; Prostate; Proteins; Sarcoma; Tumor cell lines; Tumors

In recent years, an increasing number of studies have shown that elevated expression of cyclin dependent kinase (Cdk5) contributes to the oncogenic initiation and progression of many types of cancers. In this study, we investigated the expression pattern of Cdk5 in colorectal cancer (CRC) cell lines...