Eicosanoid signalling pathways in the development and progression of colorectal cancer: novel approaches for prevention/intervention

• Published in: Cancer and metastasis reviews Vol. 30; no. 3-4; pp. 363 - 385
• Main Authors: Cathcart, Mary-Clare, Lysaght, Joanne, Pidgeon, Graham P.
• Format: Journal Article
• Language: English
• Published: Boston Springer US 01.12.2011; Springer; Springer Nature B.V
• Subjects: Animals; Arachidonic acid; Biomedical and Life Sciences; Biomedicine; Cancer; Cancer Research; Care and treatment; Cell death; Cell Transformation, Neoplastic; Cellular signal transduction; Colorectal cancer; Colorectal Neoplasms - enzymology; Colorectal Neoplasms - immunology; Colorectal Neoplasms - pathology; Colorectal Neoplasms - therapy; Cyclooxygenase Inhibitors - pharmacology; Cyclooxygenase Inhibitors - therapeutic use; Cytochrome P-450; Cytochrome P-450 Enzyme System - metabolism; Development and progression; Eicosanoids - immunology; Eicosanoids - metabolism; Humans; Lipoxygenase Inhibitors - pharmacology; Lipoxygenase Inhibitors - therapeutic use; Lipoxygenases - metabolism; Neovascularization, Pathologic - enzymology; Neovascularization, Pathologic - metabolism; Oncology; Physiological aspects; Prevention; Prostaglandin-Endoperoxide Synthases - metabolism; Signal Transduction; Unsaturated fatty acids; Cytochrome; Cyclooxygenase; Arachidonic acid; Lipoxygenase; Colorectal cancer; 450

Arachidonic acid metabolism through cyclooxygenase (COX), lipoxygenase (LOX) and cytochrome P -450 epoxygenase (EPOX) pathways leads to the generation of biologically active eicosanoids, including prostanoids, leukotrienes, hydroxyeicosatetraenoic acid, epoxyeicosatrienoic acid and hydroperoxyeicosa...