The PARK8 Locus in Autosomal Dominant Parkinsonism: Confirmation of Linkage and Further Delineation of the Disease-Containing Interval

• Published in: American journal of human genetics Vol. 74; no. 1; pp. 11 - 19
• Main Authors: Zimprich, Alexander, Müller-Myhsok, Bertram, Farrer, Matthew, Leitner, Petra, Sharma, Manu, Hulihan, Mary, Lockhart, Paul, Strongosky, Audrey, Kachergus, Jennifer, Calne, Donald B., Stoessl, Jon, Uitti, Ryan J., Pfeiffer, Ronald F., Trenkwalder, Claudia, Homann, Nikolaus, Ott, Erwin, Wenzel, Karoline, Asmus, Friedrich, Hardy, John, Wszolek, Zbigniew, Gasser, Thomas
• Format: Journal Article
• Language: English
• Published: Chicago, IL Elsevier Inc 01.01.2004; University of Chicago Press; The American Society of Human Genetics
• Subjects: Biological and medical sciences; Chromosome Mapping; European Continental Ancestry Group; Female; General aspects. Genetic counseling; Genes, Dominant; Humans; Male; Medical genetics; Medical sciences; Parkinson Disease - diagnostic imaging; Parkinson Disease - genetics; Pedigree; Tomography, Emission-Computed; Japan; Human; Nervous system diseases; Pathogenesis; Genetic determinism; Genetic disease; Parkinsonism; Symptomatology; Phenotype; Autosomal character; Genetic linkage; Genetics; Dominant character; Locus; Interval

Recently, a new locus (PARK8) for autosomal dominant parkinsonism has been identified in one large Japanese family. Linkage has been shown to a 16-cM centromeric region of chromosome 12, between markers D12S1631 and D12S339. We tested 21 white families with Parkinson disease and an inheritance patte...