Commensal Bifidobacterium Strains Enhance the Efficacy of Neo-Epitope Based Cancer Vaccines

• Published in: Vaccines (Basel) Vol. 9; no. 11; p. 1356
• Main Authors: Tomasi, Michele, Dalsass, Mattia, Beghini, Francesco, Zanella, Ilaria, Caproni, Elena, Fantappiè, Laura, Gagliardi, Assunta, Irene, Carmela, König, Enrico, Frattini, Luca, Masetti, Giulia, Isaac, Samine Jessica, Armanini, Federica, Cumbo, Fabio, Blanco-Míguez, Aitor, Grandi, Alberto, Segata, Nicola, Grandi, Guido
• Format: Journal Article
• Language: English
• Published: Basel MDPI AG 18.11.2021; MDPI
• Subjects: Animals; Antibiotics; Anticancer properties; Antitumor activity; Bifidobacterium; Cancer; Cancer immunotherapy; Cancer therapies; Cancer vaccines; E coli; Epitopes; Experiments; Gene sequencing; Homology; Immunity; Immunogenicity; Immunotherapy; Intestinal microflora; Laboratories; Lachnospiraceae; Life sciences; Lymphocytes; Lymphocytes T; Melanoma; Metagenomics; microbiome; Microbiomes; Mimicry; Mutation; OMVs; Oral administration; Peptides; personalized medicine; Proteins; rRNA 16S; Tumors; Vaccines; United States > US; Italy; Germany

A large body of data both in animals and humans demonstrates that the gut microbiome plays a fundamental role in cancer immunity and in determining the efficacy of cancer immunotherapy. In this work, we have investigated whether and to what extent the gut microbiome can influence the antitumor activ...