Effects of acute tiagabine administration on aggressive responses of adult male parolees

• Published in: Journal of psychopharmacology (Oxford) Vol. 22; no. 2; p. 144
• Main Authors: Lieving, Lori M, Cherek, Don R, Lane, Scott D, Tcheremissine, Oleg V, Nouvion, Sylvain O
• Format: Journal Article
• Language: English
• Published: United States 01.03.2008
• Subjects: Adult; Aggression - drug effects; Appetitive Behavior - drug effects; Dose-Response Relationship, Drug; Escape Reaction - drug effects; GABA Agonists - administration & dosage; GABA Agonists - adverse effects; Humans; Male; Motivation; Nipecotic Acids - administration & dosage; Nipecotic Acids - adverse effects; Prisoners - psychology

Experimental and clinical studies have supported a relationship between gamma-aminobutyric acid (GABA) and aggressive behavior in non-humans and humans. Tiagabine is a GABA uptake inhibitor that has been shown to produce acute behavioral effects in animals. In addition, tiagabine has been shown to d...