Impact of acetylation on tumor metabolism

• Published in: Molecular & cellular oncology Vol. 1; no. 3; p. e963452
• Main Authors: Zhao, Di, Li, Fu-Long, Cheng, Zhou-Li, Lei, Qun-Ying
• Format: Journal Article
• Language: English
• Published: United States Taylor & Francis 15.09.2014
• Subjects: acetylation; metabolic enzyme; oncogene; Review; tumor metabolism; tumor suppressor; acetylation; metabolic enzyme; tumor suppressor; oncogene; tumor metabolism

Acetylation of protein lysine residues is a reversible and dynamic process that is controlled by histone acetyltransferases (HATs) and deacetylases (HDACs and SIRTs). Recent studies have revealed that acetylation modulates not only nuclear proteins but also cytoplasmic or mitochondrial proteins, inc...