Micellar solubilisation enhances the antiinflammatory activities of curcumin and boswellic acids in rats with adjuvant-induced arthritis

• Published in: Nutrition (Burbank, Los Angeles County, Calif.) Vol. 54; pp. 189 - 196
• Main Authors: Khayyal, Mohamed T., El-Hazek, Rania M., El-Sabbagh, Walaa A., Frank, Jan, Behnam, Dariush, Abdel-Tawab, Mona
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01.10.2018; Elsevier Limited
• Subjects: Acids; Adjuvants; analysis of variance; anti-inflammatory activity; Antioxidants; Arthritis; Asthma; Bioavailability; blood serum; Boswellia; C-reactive protein; Curcumin; Cytokines; Diclofenac; Disease; Drug dosages; drugs; Enzymes; Human subjects; Inflammation; Inflammatory bowel disease; Interleukin 6; Lipid peroxidation; Micelles; monitoring; myeloperoxidase; Nonsteroidal anti-inflammatory drugs; Oxidative stress; Peroxidation; Proteins; rats; Rodents; Solubilization; therapeutics; tumor necrosis factor-alpha; Tumor necrosis factor-TNF; Tumor necrosis factor-α; Cairo Egypt; Germany; Egypt; Oxidative stress; Boswellia; Curcumin; Arthritis; Inflammation; Micelles

•Micellar curcumin is much more active than the native extract in inhibiting paw edema induced by adjuvant inoculation.•Reduction in paw volume is associated with a decrease in inflammatory cytokines, C-reactive protein (CRP), and myeloperoxidase (MPO).•Micellar curcumin shows potent antioxidant act...