Biomimetic nanoparticles for effective mild temperature photothermal therapy and multimodal imaging

• Published in: Journal of controlled release Vol. 347; pp. 270 - 281
• Main Authors: Shu, Xian, Chen, Yi, Yan, Ping, Xiang, Yun, Shi, Qun-Ying, Yin, Tinghui, Wang, Ping, Liu, Li-Han, Shuai, Xintao
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 01.07.2022
• Subjects: biomimetics; heat; Heat endurance; Heat shock proteins; heat stress; Hollow mesoporous Prussian blue nanoparticles; Mild temperature photothermal therapy; Multimodal imaging; neoplasm cells; neoplasms; phase transition; photothermotherapy; porous media; temperature; ultrasonics; Heat shock proteins; Multimodal imaging; Heat endurance; Mild temperature photothermal therapy; Hollow mesoporous Prussian blue nanoparticles

Downregulation of adenosine triphosphate (ATP)-dependent heat shock proteins (HSPs) can significantly reduce the tumorigenicity of cancer cells and overcome heat endurance to achieve high-performance mild temperature (≤45 °C) photothermal therapy (PTT). Herein, we designed and constructed 4T1 cancer...