Thrombospondin-1 in vascular development, vascular function, and vascular disease

• Published in: Seminars in cell & developmental biology Vol. 155; no. Pt B; pp. 32 - 44
• Main Authors: Liu, Bo, Yang, Huan, Song, Yong-Seok, Sorenson, Christine M., Sheibani, Nader
• Format: Journal Article
• Language: English
• Published: England Elsevier Ltd 01.03.2024
• Subjects: Abdominal aortic aneurysm; Angiogenesis; Cell adhesion; Cell migration; Extra cellular matrix; Humans; Neoplasms - pathology; Neovascularization, Pathologic - pathology; Ocular neovascularization; Vascular cells; Vascular Diseases; CCL5/RANTES; CFH; RPE; PC/SMC; TSP1; cGMP; CNS; CNV; Angiogenesis; CCL2/MCP-1; Cell adhesion; NG2; PDGFR; EC; AAA; Alk-1; AC; AD; VEGF; Abdominal aortic aneurysm; BMP9; PAX2; RGC; Ocular neovascularization; PDGF; TGFβ; OIR; Cell migration; Vascular cells; Extra cellular matrix

Angiogenesis is vital to developmental, regenerative and repair processes. It is normally regulated by a balanced production of pro- and anti-angiogenic factors. Alterations in this balance under pathological conditions are generally mediated through up-regulation of pro-angiogenic and/or downregula...