Thrombospondin-1 in vascular development, vascular function, and vascular disease
Angiogenesis is vital to developmental, regenerative and repair processes. It is normally regulated by a balanced production of pro- and anti-angiogenic factors. Alterations in this balance under pathological conditions are generally mediated through up-regulation of pro-angiogenic and/or downregula...
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| Published in | Seminars in cell & developmental biology Vol. 155; no. Pt B; pp. 32 - 44 |
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| Main Authors | , , , , |
| Format | Journal Article |
| Language | English |
| Published |
England
Elsevier Ltd
01.03.2024
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| Subjects | |
| Online Access | Get full text |
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| Abstract | Angiogenesis is vital to developmental, regenerative and repair processes. It is normally regulated by a balanced production of pro- and anti-angiogenic factors. Alterations in this balance under pathological conditions are generally mediated through up-regulation of pro-angiogenic and/or downregulation of anti-angiogenic factors, leading to growth of new and abnormal blood vessels. The pathological manifestation of many diseases including cancer, ocular and vascular diseases are dependent on the growth of these new and abnormal blood vessels. Thrompospondin-1 (TSP1) was the first endogenous angiogenesis inhibitor identified and its anti-angiogenic and anti-inflammatory activities have been the subject of many studies. Studies examining the role TSP1 plays in pathogenesis of various ocular diseases and vascular dysfunctions are limited. Here we will discuss the recent studies focused on delineating the role TSP1 plays in ocular vascular development and homeostasis, and pathophysiology of various ocular and vascular diseases with a significant clinical relevance to human health. |
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| AbstractList | Angiogenesis is vital to developmental, regenerative and repair processes. It is normally regulated by a balanced production of pro- and anti-angiogenic factors. Alterations in this balance under pathological conditions are generally mediated through up-regulation of pro-angiogenic and/or downregulation of anti-angiogenic factors, leading to growth of new and abnormal blood vessels. The pathological manifestation of many diseases including cancer, ocular and vascular diseases are dependent on the growth of these new and abnormal blood vessels. Thrompospondin-1 (TSP1) was the first endogenous angiogenesis inhibitor identified and its anti-angiogenic and anti-inflammatory activities have been the subject of many studies. Studies examining the role TSP1 plays in pathogenesis of various ocular diseases and vascular dysfunctions are limited. Here we will discuss the recent studies focused on delineating the role TSP1 plays in ocular vascular development and homeostasis, and pathophysiology of various ocular and vascular diseases with a significant clinical relevance to human health. Angiogenesis is vital to developmental, regenerative and repair processes. It is normally regulated by a balanced production of pro- and anti-angiogenic factors. Alterations in this balance under pathological conditions are generally mediated through up-regulation of pro-angiogenic and/or downregulation of anti-angiogenic factors, leading to growth of new and abnormal blood vessels. The pathological manifestation of many diseases including cancer, ocular and vascular diseases are dependent on the growth of these new and abnormal blood vessels. Thrompospondin-1 (TSP1) was the first endogenous angiogenesis inhibitor identified and its anti-angiogenic and anti-inflammatory activities have been the subject of many studies. Studies examining the role TSP1 plays in pathogenesis of various ocular diseases and vascular dysfunctions are limited. Here we will discuss the recent studies focused on delineating the role TSP1 plays in ocular vascular development and homeostasis, and pathophysiology of various ocular and vascular diseases with a significant clinical relevance to human health.Angiogenesis is vital to developmental, regenerative and repair processes. It is normally regulated by a balanced production of pro- and anti-angiogenic factors. Alterations in this balance under pathological conditions are generally mediated through up-regulation of pro-angiogenic and/or downregulation of anti-angiogenic factors, leading to growth of new and abnormal blood vessels. The pathological manifestation of many diseases including cancer, ocular and vascular diseases are dependent on the growth of these new and abnormal blood vessels. Thrompospondin-1 (TSP1) was the first endogenous angiogenesis inhibitor identified and its anti-angiogenic and anti-inflammatory activities have been the subject of many studies. Studies examining the role TSP1 plays in pathogenesis of various ocular diseases and vascular dysfunctions are limited. Here we will discuss the recent studies focused on delineating the role TSP1 plays in ocular vascular development and homeostasis, and pathophysiology of various ocular and vascular diseases with a significant clinical relevance to human health. |
| Author | Sorenson, Christine M. Liu, Bo Sheibani, Nader Song, Yong-Seok Yang, Huan |
| AuthorAffiliation | c Department of Pediatrics, University of Wisconsin School of Medicine and Public Health, Madison, WI 53705 b Department of Ophthalmology and Visual Sciences, University of Wisconsin School of Medicine and Public Health, Madison, WI 53705 a Department of Cell and Regenerative Biology, University of Wisconsin School of Medicine and Public Health, Madison, WI 53705 |
| AuthorAffiliation_xml | – name: a Department of Cell and Regenerative Biology, University of Wisconsin School of Medicine and Public Health, Madison, WI 53705 – name: b Department of Ophthalmology and Visual Sciences, University of Wisconsin School of Medicine and Public Health, Madison, WI 53705 – name: c Department of Pediatrics, University of Wisconsin School of Medicine and Public Health, Madison, WI 53705 |
| Author_xml | – sequence: 1 givenname: Bo surname: Liu fullname: Liu, Bo email: bliu24@wisc.edu organization: Department of Cell and Regenerative Biology, University of Wisconsin School of Medicine and Public Health, Madison, WI 53705, USA – sequence: 2 givenname: Huan surname: Yang fullname: Yang, Huan organization: Department of Cell and Regenerative Biology, University of Wisconsin School of Medicine and Public Health, Madison, WI 53705, USA – sequence: 3 givenname: Yong-Seok surname: Song fullname: Song, Yong-Seok organization: Department of Ophthalmology and Visual Sciences, University of Wisconsin School of Medicine and Public Health, Madison, WI 53705, USA – sequence: 4 givenname: Christine M. surname: Sorenson fullname: Sorenson, Christine M. organization: Department of Pediatrics, University of Wisconsin School of Medicine and Public Health, Madison, WI 53705, USA – sequence: 5 givenname: Nader orcidid: 0000-0003-2723-9217 surname: Sheibani fullname: Sheibani, Nader email: nsheibanikar@wisc.edu organization: Department of Cell and Regenerative Biology, University of Wisconsin School of Medicine and Public Health, Madison, WI 53705, USA |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/37507331$$D View this record in MEDLINE/PubMed |
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| Keywords | CCL5/RANTES CFH RPE PC/SMC TSP1 cGMP CNS CNV Angiogenesis CCL2/MCP-1 Cell adhesion NG2 PDGFR EC AAA Alk-1 AC AD VEGF Abdominal aortic aneurysm BMP9 PAX2 RGC Ocular neovascularization PDGF TGFβ OIR Cell migration Vascular cells Extra cellular matrix |
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| SubjectTerms | Abdominal aortic aneurysm Angiogenesis Cell adhesion Cell migration Extra cellular matrix Humans Neoplasms - pathology Neovascularization, Pathologic - pathology Ocular neovascularization Vascular cells Vascular Diseases |
| Title | Thrombospondin-1 in vascular development, vascular function, and vascular disease |
| URI | https://dx.doi.org/10.1016/j.semcdb.2023.07.011 https://www.ncbi.nlm.nih.gov/pubmed/37507331 https://www.proquest.com/docview/2847747082 https://pubmed.ncbi.nlm.nih.gov/PMC10811293 |
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