Neuroplasticity and MRI: A perfect match

• Published in: NeuroImage (Orlando, Fla.) Vol. 131; pp. 13 - 28
• Main Authors: Hamaide, Julie, De Groof, Geert, Van der Linden, Annemie
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01.05.2016
• Subjects: Aging - physiology; Animal; Animals; Biomedical Research - trends; Brain - physiology; Brain Mapping - trends; Cognition; Cognition - physiology; Exercise - physiology; Experience; Humans; Magnetic Resonance Imaging - methods; Models, Animal; MRI; Neuronal Plasticity - physiology; Neuroplasticity; Species Specificity; Training; ADC; BBB; RNA; Tau; Cognition; Cho; CD11b; DBM; Mn2; Training; Glu; PFF; PNN; rCBV; CA1; CA3; phMRI; MD; MnCl2; NgR; AChEI; BOLD; TBM; VBM; Neuroplasticity; AD; IGF-1; LINGO-1; fMRI; SSRI; GAP43; RD; Experience; Animal; DCX; DTI; GABA; FA; CMRO2; MRI; CBF; CNS; LTP; mRNA; PirB; SPECT; MRS; rsfMRI; CBV; NMDA; ASL; Otx2; ISH; MWM; BDNF; GFAP; NAA; CT; MEMRI; TE; PD; Ca2; TMS; CD68; ChABC; HDACI; BrdU; PET; TR
• ISSN: 1053-8119; 1095-9572; 1095-9572
• DOI: 10.1016/j.neuroimage.2015.08.005

Numerous studies have illustrated the benefits of physical workout and cognitive exercise on brain function and structure and, more importantly, on decelerating cognitive decline in old age and promoting functional rehabilitation following injury. Despite these behavioral observations, the exact mechanisms underlying these neuroplastic phenomena remain obscure. This gap illustrates the need for carefully designed in-depth studies using valid models and translational tools which allow to uncover the observed events up to the molecular level. We promote the use of in vivo magnetic resonance imaging (MRI) because it is a powerful translational imaging technique able to extract functional, structural, and biochemical information from the entire brain. Advanced processing techniques allow performing voxel-based analyses which are capable of detecting novel loci implicated in specific neuroplastic events beyond traditional regions-of-interest analyses. In addition, its non-invasive character sets it as currently the best global imaging tool for performing dynamic longitudinal studies on the same living subject, allowing thus exploring the effects of experience, training, treatment etc. in parallel to additional measures such as age, cognitive performance scores, hormone levels, and many others. The aim of this review is (i) to introduce how different animal models contributed to extend the knowledge on neuroplasticity in both health and disease, over different life stages and upon various experiences, and (ii) to illustrate how specific MRI techniques can be applied successfully to inform on the fundamental mechanisms underlying experience-dependent or activity-induced neuroplasticity including cognitive processes. •In vivo MRI allows powerful top-down research strategy.•MRI is an excellent tool to dynamically trace neuroplastic responses of the brain in vivo.•Animal research remains necessary to uncover neuroplasticity up to mechanistic level.