Characterization of Gene Expression Suppression by Bovine Coronavirus Non-Structural Protein 1

• Published in: Viruses Vol. 17; no. 7; p. 978
• Main Authors: Ohkami, Takehiro, Kitashin, Ichika, Kawashima, Riko, Yoshida, Aimi, Saito, Taizo, Takashima, Yasuhiro, Kamitani, Wataru, Nakagawa, Keisuke
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 13.07.2025; MDPI
• Subjects: Amino acids; Analysis; Animals; Antibodies; bovine coronavirus; Cattle; Cell Line; Cloning; Confocal microscopy; Control; Coronavirus, Bovine - genetics; Coronavirus, Bovine - metabolism; Coronavirus, Bovine - physiology; Coronaviruses; Cytoplasm; Diseases; Dosage and administration; Epithelial cells; Epithelial Cells - virology; Gene expression; Gene Expression Regulation; Genetic aspects; Genomes; Growth; Host-Pathogen Interactions; Identification and classification; Immunoglobulins; Lymphocytes; Lymphocytes T; Lysine; Mammary gland; non-structural protein 1; Plasmids; Proteins; Reagents; Reporter gene; ribosome; Ribosomes; Ribosomes - metabolism; Severe acute respiratory syndrome coronavirus 2; shutoff function; Viral Nonstructural Proteins - genetics; Viral Nonstructural Proteins - metabolism; Japan; United States > US; Germany; shutoff function; non-structural protein 1; ribosome; bovine coronavirus

Coronavirus non-structural protein 1 (nsp1) is a pathogenic determinant of Betacoronaviruses. Previous studies demonstrated that the nsp1 of various coronaviruses induces host shutoff through a variety of mechanisms; however, there is little information on the function of bovine coronavirus (BCoV) n...