Gasdermin D Is a Novel Prognostic Biomarker and Relates to TMZ Response in Glioblastoma

• Published in: Cancers Vol. 13; no. 22; p. 5620
• Main Authors: Liu, Junhui, Gao, Lun, Zhu, Xiaonan, Geng, Rongxin, Tao, Xiang, Xu, Haitao, Chen, Zhibiao
• Format: Journal Article
• Language: English
• Published: Basel MDPI AG 10.11.2021; MDPI
• Subjects: Antibodies; Antigens; Bioinformatics; Biomarkers; Brain cancer; Chemotherapy; Correlation analysis; Datasets; Enzyme-linked immunosorbent assay; gasdermin family; Gene expression; Glioblastoma; Glioma; IL-1β; immune; Immunofluorescence; Immunohistochemistry; Infiltration; Macrophages; Medical prognosis; Mesenchyme; Metastases; Microwaves; Mutation; prognosis; Proteins; Pyroptosis; Radiation therapy; Risk factors; Survival analysis; temozolomide; Tumors; United States > US; China

The gasdermin (GSDM) family act as executioners during pyroptosis. However, its expression and biological role in glioma remain to be determined. This study carried out gene expression from six public datasets. Westerns blots and immunohistochemistry (IHC) staining were employed to examine GSDM expr...