Economic Evaluation of Interventions for Treatment of Neonatal Opioid Withdrawal Syndrome: A Review
This study assessed the economic evidence on the pharmacological and non-pharmacological management of infants with neonatal opioid withdrawal syndrome (NOWS). Six databases were searched up to October 2020 for peer-reviewed studies. After titles and abstracts were screened, 79 studies remained for...
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Published in | Children (Basel) Vol. 8; no. 7; p. 534 |
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Main Authors | , , , |
Format | Journal Article |
Language | English |
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Abstract | This study assessed the economic evidence on the pharmacological and non-pharmacological management of infants with neonatal opioid withdrawal syndrome (NOWS). Six databases were searched up to October 2020 for peer-reviewed studies. After titles and abstracts were screened, 79 studies remained for full-text review, and finally, 8 studies were eligible for inclusion in the review. The methodological quality of included studies was assessed using the Drummond checklist. The review showed significant limitations in these studies, with one study being rated as good and the remaining seven studies as of poor quality. There are methodological issues that require addressing, including a lack of detail on cost categories, a robust investigation of uncertainty, and extending the time horizon to consider longer-term outcomes beyond the initial birth hospitalization. Despite these limitations, existing evidence suggests non-pharmacological strategies such as rooming-in were associated with a shorter hospital stay and a decreased need for pharmacological treatment, thereby lowering hospitalization costs. The review highlights the paucity of high-quality studies assessing the cost-effectiveness of intervention strategies for NOWS. There is also a lack of evidence on long-term outcomes associated with NOWS and the treatment of NOWS. The inclusion of economic analyses in future studies will provide evidence to inform policymakers on resource allocation decisions for this patient population. |
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AbstractList | This study assessed the economic evidence on the pharmacological and non-pharmacological management of infants with neonatal opioid withdrawal syndrome (NOWS). Six databases were searched up to October 2020 for peer-reviewed studies. After titles and abstracts were screened, 79 studies remained for full-text review, and finally, 8 studies were eligible for inclusion in the review. The methodological quality of included studies was assessed using the Drummond checklist. The review showed significant limitations in these studies, with one study being rated as good and the remaining seven studies as of poor quality. There are methodological issues that require addressing, including a lack of detail on cost categories, a robust investigation of uncertainty, and extending the time horizon to consider longer-term outcomes beyond the initial birth hospitalization. Despite these limitations, existing evidence suggests non-pharmacological strategies such as rooming-in were associated with a shorter hospital stay and a decreased need for pharmacological treatment, thereby lowering hospitalization costs. The review highlights the paucity of high-quality studies assessing the cost-effectiveness of intervention strategies for NOWS. There is also a lack of evidence on long-term outcomes associated with NOWS and the treatment of NOWS. The inclusion of economic analyses in future studies will provide evidence to inform policymakers on resource allocation decisions for this patient population. |
Author | Azim, Syeda Oei, Ju Lee, Evelyn Schofield, Deborah |
AuthorAffiliation | 1 Centre for Economic Impacts of Genomic Medicine, Macquarie University, North Ryde, NSW 2109, Australia; deborah.schofield@mq.edu.au 2 School of Women’s and Children’s Health, University of New South Wales, Kensington, NSW 2031, Australia; syeda_ishra.azim@unsw.edu.au (S.I.A.); j.oei@unsw.edu.au (J.L.O.) |
AuthorAffiliation_xml | – name: 1 Centre for Economic Impacts of Genomic Medicine, Macquarie University, North Ryde, NSW 2109, Australia; deborah.schofield@mq.edu.au – name: 2 School of Women’s and Children’s Health, University of New South Wales, Kensington, NSW 2031, Australia; syeda_ishra.azim@unsw.edu.au (S.I.A.); j.oei@unsw.edu.au (J.L.O.) |
Author_xml | – sequence: 1 givenname: Evelyn orcidid: 0000-0002-4434-1304 surname: Lee fullname: Lee, Evelyn – sequence: 2 givenname: Deborah orcidid: 0000-0002-1658-494X surname: Schofield fullname: Schofield, Deborah – sequence: 3 givenname: Syeda surname: Azim fullname: Azim, Syeda – sequence: 4 givenname: Ju orcidid: 0000-0002-7799-3771 surname: Oei fullname: Oei, Ju |
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SubjectTerms | Cost analysis Cost control Cost estimates cost-effectiveness Data collection Drug withdrawal economic evaluation Intervention Length of stay Narcotics Neonatal abstinence syndrome neonatal opioid withdrawal syndrome neonatal withdrawal syndrome Newborn babies opioid exposed Pediatrics Systematic Review |
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Title | Economic Evaluation of Interventions for Treatment of Neonatal Opioid Withdrawal Syndrome: A Review |
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