Squamous cell carcinoma of head and neck: what internists should know

Squamous cell carcinoma of head and neck (SCCHN) is a group of cancer arising from mucosal surfaces of the head and neck. Optimal management of SCCHN requires a multidisciplinary team of surgical oncologists, radiation oncologists, medical oncologists, nutritionist, and speech-language pathologists,...

Full description

Saved in:
Bibliographic Details
Published inThe Korean journal of internal medicine Vol. 35; no. 5; pp. 1031 - 1044
Main Authors Jung, Kyungsuk, Narwal, Manpreet, Min, Seon Young, Keam, Bhumsuk, Kang, Hyunseok
Format Journal Article
LanguageEnglish
Published The Korean Association of Internal Medicine 01.09.2020
대한내과학회
Subjects
drug therapy
head and neck neoplasms
papillomaviridae
Review
survivorship
내과학
Online AccessGet full text

Cover

Abstract Squamous cell carcinoma of head and neck (SCCHN) is a group of cancer arising from mucosal surfaces of the head and neck. Optimal management of SCCHN requires a multidisciplinary team of surgical oncologists, radiation oncologists, medical oncologists, nutritionist, and speech-language pathologists, due to the complexity of anatomical structure and importance of functional outcome. Human papilloma virus (HPV)-related SCCHN represents a distinct subset from HPV negative SCCHN which is associated with carcinogen exposure such as cigarette smoking, betel nut use and alcohol. HPV related SCCHN responds better to concurrent chemoradiation and has better overall prognosis, compared to HPV negative SCCHN. Radiation therapy has been introduced to the treatment of SCCHN, administered concurrently with systemic chemotherapy for locoregional SCCHN, as well as a palliative measure for recurrent and/or metastatic (R/M) SCCHN. Recently, immune checkpoint inhibitors have been shown to improve overall survival in R/M-SCCHN and have been incorporated into the standard of care. Combination approaches with immune therapy and targeted therapy for biomarker enriched population based on genomics are being actively investigated and will shape the future of SCCHN treatment.
AbstractList Squamous cell carcinoma of head and neck (SCCHN) is a group of cancer arising from mucosal surfaces of the head and neck. Optimal management of SCCHN requires a multidisciplinary team of surgical oncologists, radiation oncologists, medical oncologists, nutritionist, and speech-language pathologists, due to the complexity of anatomical structure and importance of functional outcome. Human papilloma virus (HPV)-related SCCHN represents a distinct subset from HPV negative SCCHN which is associated with carcinogen exposure such as cigarette smoking, betel nut use and alcohol. HPV related SCCHN responds better to concurrent chemoradiation and has better overall prognosis, compared to HPV negative SCCHN. Radiation therapy has been introduced to the treatment of SCCHN, administered concurrently with systemic chemotherapy for locoregional SCCHN, as well as a palliative measure for recurrent and/or metastatic (R/M) SCCHN. Recently, immune checkpoint inhibitors have been shown to improve overall survival in R/M-SCCHN and have been incorporated into the standard of care. Combination approaches with immune therapy and targeted therapy for biomarker enriched population based on genomics are being actively investigated and will shape the future of SCCHN treatment.
Squamous cell carcinoma of head and neck (SCCHN) is a group of cancer arising from mucosal surfaces of the head and neck. Optimal management of SCCHN requires a multidisciplinary team of surgical oncologists, radiation oncologists, medical oncologists, nutritionist, and speech-language pathologists, due to the complexity of anatomical structure and importance of functional outcome. Human papilloma virus (HPV)-related SCCHN represents a distinct subset from HPV negative SCCHN which is associated with carcinogen exposure such as cigarette smoking, betel nut use and alcohol. HPV related SCCHN responds better to concurrent chemoradiation and has better overall prognosis, compared to HPV negative SCCHN. Radiation therapy has been introduced to the treatment of SCCHN, administered concurrently with systemic chemotherapy for locoregional SCCHN, as well as a palliative measure for recurrent and/or metastatic (R/M) SCCHN. Recently, immune checkpoint inhibitors have been shown to improve overall survival in R/M-SCCHN and have been incorporated into the standard of care. Combination approaches with immune therapy and targeted therapy for biomarker enriched population based on genomics are being actively investigated and will shape the future of SCCHN treatment. KCI Citation Count: 0
Author Min, Seon Young
Narwal, Manpreet
Kang, Hyunseok
Jung, Kyungsuk
Keam, Bhumsuk
Author_xml – sequence: 1
  givenname: Kyungsuk
  surname: Jung
  fullname: Jung, Kyungsuk
– sequence: 2
  givenname: Manpreet
  surname: Narwal
  fullname: Narwal, Manpreet
– sequence: 3
  givenname: Seon Young
  surname: Min
  fullname: Min, Seon Young
– sequence: 4
  givenname: Bhumsuk
  surname: Keam
  fullname: Keam, Bhumsuk
– sequence: 5
  givenname: Hyunseok
  surname: Kang
  fullname: Kang, Hyunseok
BackLink https://www.kci.go.kr/kciportal/ci/sereArticleSearch/ciSereArtiView.kci?sereArticleSearchBean.artiId=ART002615971$$DAccess content in National Research Foundation of Korea (NRF)
BookMark eNpVkc1r3DAQxUVJaTZpj73r2oO3ow_Lcg-FENJ2IRBI07MYS3JWa1tKJW9C__t6d0shh2FgZt6PN7wLchZT9IR8ZLAWLcjPwy5Maw4c1tDoN2TFAepKKanPyIpxriohQJyTi1J2AKoBLd6Rc8GVEi0TK3Lz8_cep7Qv1PpxpBazDTFNSFNPtx4dxeho9Hb4Ql-2ONMQZ59jKHOhZZv2o6NDTC_vydsex-I__OuX5Ne3m4frH9Xt3ffN9dVtZaWSc4UNKq6tVq5WNTjQjUBED7zRSi_lGbOctz3zskdnsW1awTrBLciei9qLS_LpxI25N4MNJmE49sdkhmyu7h82pq1rKYRcbjenW5dwZ55ymDD_OQqOg5QfDeY52NEb3YFCUJ1VXSe7TmmGi7_aSe-wbyVbWF9PrKd9N3lnfZwzjq-grzcxbBdPz6aRy4_QLoDqBLA5lZJ9_1_LwBxyNIcczSFHs-Qo_gKrdZFn
CitedBy_id crossref_primary_10_1186_s12935_021_02394_w
crossref_primary_10_1007_s13353_024_00842_7
crossref_primary_10_3389_fcell_2021_803981
crossref_primary_10_3390_cancers15184551
crossref_primary_10_12677_ACM_2023_13122700
crossref_primary_10_3233_CBM_220350
crossref_primary_10_1097_MD_0000000000037824
crossref_primary_10_7759_cureus_51692
crossref_primary_10_1016_j_arabjc_2023_105561
crossref_primary_10_7759_cureus_22569
crossref_primary_10_1007_s00405_024_08765_z
crossref_primary_10_1007_s10528_023_10489_4
crossref_primary_10_1111_jop_13566
crossref_primary_10_3390_cancers14153755
crossref_primary_10_3390_vaccines10081272
crossref_primary_10_1155_2022_4552445
crossref_primary_10_3892_mco_2023_2624
crossref_primary_10_1002_jcla_24722
crossref_primary_10_1016_j_apmt_2023_101886
crossref_primary_10_1007_s11655_022_3674_9
Cites_doi 10.1002/cncr.29323
10.1001/jamaoncol.2018.4051
10.1001/archotol.129.1.44
10.1084/jem.20090847
10.1001/jama.2012.101
10.1007/BF00184668
10.1056/NEJM200104123441503
10.1200/JCO.2016.70.1524
10.1200/JCO.2013.54.5228
10.1001/jamaoto.2013.4072
10.1002/lary.27610
10.1177/0022034509343143
10.1186/s40463-018-0321-8
10.1056/NEJMoa032641
10.1200/JCO.2017.76.2591
10.1016/j.ijrobp.2019.08.038
10.1053/j.ro.2012.09.002
10.1200/JCO.2012.43.6097
10.1002/ijc.11633
10.1200/JCO.1999.17.1.352
10.1016/S0140-6736(19)32591-7
10.1093/annonc/mdu167
10.1002/cncr.23442
10.1016/S1470-2045(13)70244-4
10.4143/crt.2018.143
10.1016/j.mayocp.2015.12.017
10.1200/JCO.2004.08.021
10.1016/j.arcmed.2007.08.003
10.1001/archotol.129.1.106
10.1590/S0104-42302011000200014
10.1093/jnci/92.9.690
10.1186/1916-0216-42-30
10.1093/jnci/djn025
10.1016/j.cytogfr.2016.02.001
10.1200/JCO.2016.68.3300
10.1056/NEJM199802123380703
10.1007/s00520-010-0873-2
10.1016/j.oraloncology.2013.09.008
10.1016/S1470-2045(17)30421-7
10.1200/JCO.2012.43.8820
10.1002/pon.3388
10.3322/caac.21551
10.1016/j.oraloncology.2015.06.009
10.1016/S1470-2045(19)30410-3
10.1093/jnci/91.24.2081
10.1002/hed.21159
10.1126/scitranslmed.3003130
10.1007/s00405-015-3526-8
10.1016/j.ijrobp.2005.05.004
10.1056/NEJMoa053422
10.4103/0973-1482.183176
10.1186/s41199-018-0030-z
10.1016/j.oraloncology.2019.104523
10.1016/j.oraloncology.2018.10.028
10.3322/caac.21343
10.1001/archoto.2011.234
10.1002/(SICI)1097-0215(19961115)68:4<506::AID-IJC17>3.0.CO;2-2
10.1056/NEJMoa031317
10.1002/(SICI)1097-4644(20000801)78:2<334::AID-JCB15>3.0.CO;2-F
10.1016/j.pvr.2018.12.002
10.1002/cam4.1108
10.2307/3574476
10.1126/science.1146073
10.3322/caac.21157
10.1056/NEJMoa065497
10.1056/NEJMoa0912217
10.1001/jamaoto.2013.3210
10.1200/JCO.2014.55.1937
10.1038/35096067
10.1016/S0140-6736(18)32779-X
10.7326/M17-1363
10.1200/JCO.1998.16.4.1318
10.1016/S1470-2045(13)70011-1
10.1200/JCO.2017.75.0141
10.1016/0360-3016(87)90076-9
10.1056/NEJMoa0802656
10.1200/JCO.2015.61.3836
10.1002/ijc.30516
10.1097/PSY.0000000000000256
10.1073/pnas.1009933108
10.1002/hed.23465
10.1056/NEJMoa032646
10.1016/S0140-6736(18)32752-1
10.1016/j.oraloncology.2008.09.004
10.1016/j.humpath.2019.05.006
10.1016/j.ijrobp.2009.01.058
10.1200/JCO.2003.01.008
10.1158/1535-7163.TARG-19-PR08
10.1038/nature04374
10.1016/j.otohns.2004.02.035
10.1056/NEJMoa1602252
10.1200/JCO.19.01507
10.1200/JCO.2013.54.6309
10.1002/hed.24268
10.1016/j.mrrev.2016.08.001
ContentType Journal Article
Copyright Copyright © 2020 The Korean Association of Internal Medicine 2020
Copyright_xml – notice: Copyright © 2020 The Korean Association of Internal Medicine 2020
DBID AAYXX
CITATION
5PM
DOA
ACYCR
DOI 10.3904/kjim.2020.078
DatabaseName CrossRef
PubMed Central (Full Participant titles)
DOAJ Directory of Open Access Journals
Korean Citation Index
DatabaseTitle CrossRef
DatabaseTitleList


Database_xml – sequence: 1
  dbid: DOA
  name: DOAJ Directory of Open Access Journals
  url: https://www.doaj.org/
  sourceTypes: Open Website
DeliveryMethod fulltext_linktorsrc
Discipline Medicine
EISSN 2005-6648
EndPage 1044
ExternalDocumentID oai_kci_go_kr_ARTI_9554334
oai_doaj_org_article_8b06a06bc6bb4bb681a6505d4edaf941
10_3904_kjim_2020_078
GroupedDBID ---
123
29L
8XY
9ZL
AAYXX
ACYCR
ADBBV
AENEX
ALMA_UNASSIGNED_HOLDINGS
AOIJS
BAWUL
BCNDV
CITATION
DIK
DU5
E3Z
F5P
FRP
GROUPED_DOAJ
GX1
HYE
HZB
KQ8
M48
M~E
OK1
PGMZT
RPM
5PM
85H
ADRAZ
MZR
ZXP
ZZE
ID FETCH-LOGICAL-c464t-a7a628c86d5650d0873aaae027868786e11c229f1e4fadca97931b32c04f235e3
IEDL.DBID RPM
ISSN 1226-3303
IngestDate Tue Nov 21 21:40:24 EST 2023
Tue Oct 22 15:12:04 EDT 2024
Tue Sep 17 21:12:27 EDT 2024
Fri Aug 23 00:28:53 EDT 2024
IsDoiOpenAccess true
IsOpenAccess true
IsPeerReviewed true
IsScholarly true
Issue 5
Language English
License This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/) which permits unrestricted noncommercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
LinkModel DirectLink
MergedId FETCHMERGED-LOGICAL-c464t-a7a628c86d5650d0873aaae027868786e11c229f1e4fadca97931b32c04f235e3
OpenAccessLink https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7487309/
PMID 32663913
PageCount 14
ParticipantIDs nrf_kci_oai_kci_go_kr_ARTI_9554334
doaj_primary_oai_doaj_org_article_8b06a06bc6bb4bb681a6505d4edaf941
pubmedcentral_primary_oai_pubmedcentral_nih_gov_7487309
crossref_primary_10_3904_kjim_2020_078
PublicationCentury 2000
PublicationDate 2020-09-01
PublicationDateYYYYMMDD 2020-09-01
PublicationDate_xml – month: 09
  year: 2020
  text: 2020-09-01
  day: 01
PublicationDecade 2020
PublicationTitle The Korean journal of internal medicine
PublicationYear 2020
Publisher The Korean Association of Internal Medicine
대한내과학회
Publisher_xml – name: The Korean Association of Internal Medicine
– name: 대한내과학회
References ref13
ref57
ref12
ref56
ref15
ref59
ref14
ref58
ref53
ref52
ref96
ref11
ref55
ref10
ref54
ref17
ref16
ref19
ref18
ref93
ref92
ref51
ref95
ref50
ref94
ref91
ref90
ref46
ref45
ref89
ref48
ref47
ref42
ref86
ref41
ref85
ref44
ref88
ref43
ref87
(ref25) 2015
ref49
ref8
ref7
ref9
ref4
ref3
ref6
ref5
ref82
ref81
ref40
ref84
ref83
ref80
ref35
ref79
ref34
ref78
ref37
ref36
ref31
ref75
ref30
ref74
ref33
ref77
ref32
ref76
ref2
ref1
ref39
ref38
ref71
ref70
ref73
ref72
ref24
ref68
ref23
ref67
ref26
ref69
ref20
ref64
ref63
ref22
ref66
ref21
ref65
ref28
ref27
ref29
ref60
ref62
ref61
References_xml – ident: ref56
  doi: 10.1002/cncr.29323
– ident: ref94
  doi: 10.1001/jamaoncol.2018.4051
– ident: ref69
  doi: 10.1001/archotol.129.1.44
– ident: ref61
  doi: 10.1084/jem.20090847
– ident: ref10
  doi: 10.1001/jama.2012.101
– start-page: 576
  volume-title: Comprehensive genomic characterization of head and neck squamous cell carcinomas
  year: 2015
  ident: ref25
– ident: ref5
  doi: 10.1007/BF00184668
– ident: ref13
  doi: 10.1056/NEJM200104123441503
– ident: ref63
  doi: 10.1200/JCO.2016.70.1524
– ident: ref32
  doi: 10.1200/JCO.2013.54.5228
– ident: ref89
  doi: 10.1001/jamaoto.2013.4072
– ident: ref75
  doi: 10.1002/lary.27610
– ident: ref78
  doi: 10.1177/0022034509343143
– ident: ref70
  doi: 10.1186/s40463-018-0321-8
– ident: ref46
  doi: 10.1056/NEJMoa032641
– ident: ref50
  doi: 10.1200/JCO.2017.76.2591
– ident: ref93
  doi: 10.1016/j.ijrobp.2019.08.038
– ident: ref1
  doi: 10.1053/j.ro.2012.09.002
– ident: ref45
  doi: 10.1200/JCO.2012.43.6097
– ident: ref15
  doi: 10.1002/ijc.11633
– ident: ref87
  doi: 10.1200/JCO.1999.17.1.352
– ident: ref66
  doi: 10.1016/S0140-6736(19)32591-7
– ident: ref57
  doi: 10.1093/annonc/mdu167
– ident: ref60
  doi: 10.1002/cncr.23442
– ident: ref90
  doi: 10.1016/S1470-2045(13)70244-4
– ident: ref3
  doi: 10.4143/crt.2018.143
– ident: ref35
  doi: 10.1016/j.mayocp.2015.12.017
– ident: ref41
  doi: 10.1200/JCO.2004.08.021
– ident: ref16
  doi: 10.1016/j.arcmed.2007.08.003
– ident: ref6
  doi: 10.1001/archotol.129.1.106
– ident: ref85
  doi: 10.1590/S0104-42302011000200014
– ident: ref21
  doi: 10.1093/jnci/92.9.690
– ident: ref36
  doi: 10.1186/1916-0216-42-30
– ident: ref12
  doi: 10.1093/jnci/djn025
– ident: ref19
  doi: 10.1016/j.cytogfr.2016.02.001
– ident: ref92
  doi: 10.1200/JCO.2016.68.3300
– ident: ref20
  doi: 10.1056/NEJM199802123380703
– ident: ref79
  doi: 10.1007/s00520-010-0873-2
– ident: ref82
  doi: 10.1016/j.oraloncology.2013.09.008
– ident: ref65
  doi: 10.1016/S1470-2045(17)30421-7
– ident: ref51
  doi: 10.1200/JCO.2012.43.8820
– ident: ref86
  doi: 10.1002/pon.3388
– ident: ref2
  doi: 10.3322/caac.21551
– ident: ref80
  doi: 10.1016/j.oraloncology.2015.06.009
– ident: ref37
  doi: 10.1016/S1470-2045(19)30410-3
– ident: ref40
  doi: 10.1093/jnci/91.24.2081
– ident: ref55
  doi: 10.1002/hed.21159
– ident: ref62
  doi: 10.1126/scitranslmed.3003130
– ident: ref72
  doi: 10.1007/s00405-015-3526-8
– ident: ref74
  doi: 10.1016/j.ijrobp.2005.05.004
– ident: ref52
  doi: 10.1056/NEJMoa053422
– ident: ref71
  doi: 10.4103/0973-1482.183176
– ident: ref31
  doi: 10.1186/s41199-018-0030-z
– ident: ref67
  doi: 10.1016/j.oraloncology.2019.104523
– ident: ref76
  doi: 10.1016/j.oraloncology.2018.10.028
– ident: ref84
  doi: 10.3322/caac.21343
– ident: ref88
  doi: 10.1001/archoto.2011.234
– ident: ref33
  doi: 10.1002/(SICI)1097-0215(19961115)68:4<506::AID-IJC17>3.0.CO;2-2
– ident: ref43
  doi: 10.1056/NEJMoa031317
– ident: ref34
  doi: 10.1002/(SICI)1097-4644(20000801)78:2<334::AID-JCB15>3.0.CO;2-F
– ident: ref14
  doi: 10.1016/j.pvr.2018.12.002
– ident: ref27
  doi: 10.1002/cam4.1108
– ident: ref38
  doi: 10.2307/3574476
– ident: ref28
  doi: 10.1126/science.1146073
– ident: ref81
  doi: 10.3322/caac.21157
– ident: ref7
  doi: 10.1056/NEJMoa065497
– ident: ref8
  doi: 10.1056/NEJMoa0912217
– ident: ref30
  doi: 10.1001/jamaoto.2013.3210
– ident: ref9
  doi: 10.1200/JCO.2014.55.1937
– ident: ref29
  doi: 10.1038/35096067
– ident: ref53
  doi: 10.1016/S0140-6736(18)32779-X
– ident: ref11
  doi: 10.7326/M17-1363
– ident: ref44
  doi: 10.1200/JCO.1998.16.4.1318
– ident: ref48
  doi: 10.1016/S1470-2045(13)70011-1
– ident: ref17
  doi: 10.1200/JCO.2017.75.0141
– ident: ref39
  doi: 10.1016/0360-3016(87)90076-9
– ident: ref59
  doi: 10.1056/NEJMoa0802656
– ident: ref68
  doi: 10.1200/JCO.2015.61.3836
– ident: ref23
  doi: 10.1002/ijc.30516
– ident: ref91
  doi: 10.1097/PSY.0000000000000256
– ident: ref22
  doi: 10.1073/pnas.1009933108
– ident: ref73
  doi: 10.1002/hed.23465
– ident: ref47
  doi: 10.1056/NEJMoa032646
– ident: ref54
  doi: 10.1016/S0140-6736(18)32752-1
– ident: ref83
  doi: 10.1016/j.oraloncology.2008.09.004
– ident: ref24
  doi: 10.1016/j.humpath.2019.05.006
– ident: ref77
  doi: 10.1016/j.ijrobp.2009.01.058
– ident: ref42
  doi: 10.1200/JCO.2003.01.008
– ident: ref95
  doi: 10.1158/1535-7163.TARG-19-PR08
– ident: ref26
  doi: 10.1038/nature04374
– ident: ref4
  doi: 10.1016/j.otohns.2004.02.035
– ident: ref64
  doi: 10.1056/NEJMoa1602252
– ident: ref96
  doi: 10.1200/JCO.19.01507
– ident: ref49
  doi: 10.1200/JCO.2013.54.6309
– ident: ref58
  doi: 10.1002/hed.24268
– ident: ref18
  doi: 10.1016/j.mrrev.2016.08.001
SSID ssj0067083
Score 2.3738108
SecondaryResourceType review_article
Snippet Squamous cell carcinoma of head and neck (SCCHN) is a group of cancer arising from mucosal surfaces of the head and neck. Optimal management of SCCHN requires...
SourceID nrf
doaj
pubmedcentral
crossref
SourceType Open Website
Open Access Repository
Aggregation Database
StartPage 1031
SubjectTerms drug therapy
head and neck neoplasms
papillomaviridae
Review
survivorship
내과학
SummonAdditionalLinks – databaseName: DOAJ Directory of Open Access Journals
  dbid: DOA
  link: http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwrV1NT9wwELUQB8SlohTE0hZZVdVbWCd2nIRbQbuilegFkLhZ4y92WZGl-yH-PjPOgnZ74dJDFCkfivMmid8bO28Y-x5BS1BWZj6n1I2OIrPOh6z0VgtPDnTJXf_qj768Vb_vyru1Ul80J6yzB-6A69dWaBDaOm2tslbXOSCpKL0KHmKjOuEjmlcx1X2DdSWSAWeO5CJDxS47d03U96o_eRjTH-iFOBVUW22tN0qm_djHtLP47xTJtT5nuMc-rMgi_9k18iPbCu0-27laDYd_YoPrv0sg7c4p_84d1QVqp4_Ap5HjR9ZzaD1vg5uc8ecRLPg4pf8wsHM-H1Fta04ptQN2OxzcXFxmq7oImVNaLTKoQBe1q7VHNpYAlQAQaAxR17iEPHdF0cQ8qAjeQYPvYG5l4YSKhSyDPGTb7bQNR4wnO1QZUdV4qQKqr6Ch1FWTN66EoHSP_XjFxzx19hcGZQMBaQhIQ0AaBLLHzgm9t4PItTptwFiaVSzNe7HssW-IvZm4cTqf1vdTM5kZ5Pa_TIPMR0rVY9VGaDYuubmnHY-SYXaFqkyK5vh_tPEz26V77qaZfWHbi9kyfEVesrAn6RF8ARTb4DA
  priority: 102
  providerName: Directory of Open Access Journals
– databaseName: Scholars Portal Open Access Journals
  dbid: M48
  link: http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwjV1Lb9QwELagSIhLxVNsechCiFuKHTtOglQhQK0KUrnASr1Z41d3WZq02a0K_54ZbygscOAQJUpiWf4cZ-Yb298w9jyBUaCdKoKk0I1JonA-xKIKzohACnRZXf_oozmc6g_H1fEvSaERwOU_qR3lk5oOX3e_nX9_jQN-jxhnK_TLxZc57SkvxS7au-vsRkm7gGgVn76aUDC1yIqcEr2NAim8Wstt_l18wzxlFX80Ot2Q_lwz-ZsROrjNtkfvkb9Zd_cddi12d9nNo3F-_B7b_3R-AUTmOQXkuadEQV1_CrxPHP-6gUMXeBf94hW_nMGKz3M8EHt6yZczSnbNKcZ2n00P9j-_OyzGRAmF10avCqjBlI1vTED3LCOsACDSpKJp8IhS-rJsk4w6QfDQ4qCUTpVe6FSqKqoHbKvru_iQ8ayPqhLSnKB0RDoWDVSmbmXrK4jaTNiLn_jYs7UehkUeQUBaAtISkBaBnLC3hN7VSyRjnW_0w4kdR4VtnDAgjPPGOe2caSRgA6qgY4DUajlhzxB7u_DzXJ7OJ71dDBad_fe2RVdIKT1h9UbXbFS5-aSbz7KCdo00TYl2538b84jdosv12rLHbGs1XMQn6Iys3NP8mf0APYzc7w
  priority: 102
  providerName: Scholars Portal
Title Squamous cell carcinoma of head and neck: what internists should know
URI https://pubmed.ncbi.nlm.nih.gov/PMC7487309
https://doaj.org/article/8b06a06bc6bb4bb681a6505d4edaf941
https://www.kci.go.kr/kciportal/ci/sereArticleSearch/ciSereArtiView.kci?sereArticleSearchBean.artiId=ART002615971
Volume 35
hasFullText 1
inHoldings 1
isFullTextHit
isPrint
ispartofPNX The Korean Journal of Internal Medicine, 2020, 35(5), , pp.1031-1044
link http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV3PT9swFH4CDojLNPZD6waVhabd0sax4yS7bQgEmzpN2pC4Wf5JQ1cHStH-_T076bTuyCGxlMRK_Oz4fZ_9_BngvVeCKa5ZZmkcuhE-z7SxLiutFrmNCnRJXX_2TVxc8S_X5fUOlJu1MClo3-h2En4tJ6Gdp9jKu6WZbuLEpt9npxWibJY3013YxXRD0fvuV1R50t6kiCsyJOusF9ZEas-ni9s2Lj4v8gk6xgPYR-iCDpqyLZ-UpPvR04SV_z9Q8h_Pc_4cng2QkXzqP-0Qdlx4AfuzYVL8JZz9uH9UkcGTOApPTNwdKHRLRTpPsKu1RAVLgjOLj-T3XK1JmwYBsXofyMM87nBN4sDaK7g6P_t5epENuyNkhgu-zlSlRFGbWljEZMmsTCnl4kyiqPFwlJqiaDx13CtrVIN_ItWsMDn3BSsdew17oQvuDZAkiso8chvLuEMO5oQqRdXQxpTKcTGCDxv7yLteBEMieYg2ldGmMtpUok1H8Dla7-9DUbs6XehWN3KoQVnrXKhcaCO05lqLmiosQGm5s8o3nI7gBG0vF6ZN-WN608nFSiLCv5QN4h_G-AiqrarZeuX2HWxFSTZ7aDVvn5zzHRzEgvYRZkewt149umOEJGs9RjB--XWcCD2eZ7wep0b5B-x74ro
link.rule.ids 230,315,730,783,787,867,888,2109,2228,24331,27937,27938,53805,53807
linkProvider National Library of Medicine
linkToHtml http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV1Lb9QwEB6VIpVeeFcsTwshbskmseMk3KBqtYVuhUSLerP8Sjekm7TbrJD49YydBLG9wSGKFMdK7M_2PDz-BuBdKTmVTNHAxM51w8soUNrYIDWKR8Yx0Hl2_fkJn52xz-fp-Rak41kYH7SvVRU2l8uwqRY-tvJqqadjnNj063w_Qy2bRsX0DtzF-Rqlo5HeL8A8izz7ZoyaRYDmOu2pNdG4Z9P6R-WOnydRiKJxF3ZQeUERHdMNqeTJ-1HWNKvydqjkX7Ln8AF8H_-6Dzmpw3WnQv3rFqHjPzfrIdwftFHysS9-BFu2eQw782G__QkcfLteS-ccIM7BT7RLPNS0S0nakuAqbohsDGmsrj-QnwvZkcr7F3Hk3JCbhUueTZzP7imcHR6c7s-CIfFCoBlnXSAzyZNc59yguucRo1JK6zYpeY6XjWOdJEUZW1ZKo2WBkzxWNNERKxOaWroH203b2GdAPN8qLdFsMpRZNO8slynPirjQqbSMT-D92PHiqufXEGiXOLCEA0s4sASCNYFPDpY_LzlabP-gXV2IoRdFriIuI640V4opxfNYYgNSw6yRZcHiCbxFUEWtK1_f3S9aUa8EGg9HokDVilI2gWwD841PbpYgkp6Re0Du-X_XfAP3ZqfzY3F8dPLlBey6RveBbC9hu1ut7SvUfDr12o_z32_5Af4
linkToPdf http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV1Jb9QwFLagSKNe2BHDaiHELYtjx0m4QemoBaaqBJUqLpbXTgiTDNOMkPj1PDsZ1OmxhyhSYit5_hy_xS_fQ-itk5xKpmhkiA_dcJdGShsb5Ubx1HgGusCuPz_hR2fs83l-fqXUV0ja16qO21_LuK0XIbdytdTJNk8sOZ0fFGBl07RKVsYlt9Gd3JOmbx31YRHmRRoYOAlYFxG47HSg1wQHnyXNz9r_gp6lMajHfTQBAwbUNKE7mikQ-IO-adfuerrkFf0zu4d-bN98SDtp4k2vYv33GqnjjUS7j-6OVin-MDR5gG7Z9iGazMd990fo8NvvjfRBAuwD_Vj7AkRtt5S4cxhWc4Nla3BrdfMe_1nIHtchzggz6BJfLnwRbexjd4_R2ezw-8FRNBZgiDTjrI9kIXlW6pIbMPsCclRKaf1mJS_hsIToLKscscxJo2UFHztRNNMpcxnNLX2C9tqutU8RDryr1IH7ZCiz4OZZLnNeVKTSubSMT9G77eCL1cCzIcA_8YAJD5jwgAkAbIo-emj-N_L02OFCt74Q40iKUqVcplxprhRTipdEggC5YdZIVzEyRW8AWNHoOvT354tONGsBTsSxqMDEopRNUbGD-84jd-8AmoGZe0Tv2Y17vkaT008z8fX45MtztO9lHvLZXqC9fr2xL8EA6tWrMNX_AZURBH4
openUrl ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Squamous+cell+carcinoma+of+head+and+neck%3A+what+internists+should+know&rft.jtitle=The+Korean+journal+of+internal+medicine&rft.au=Jung%2C+Kyungsuk&rft.au=Narwal%2C+Manpreet&rft.au=Min%2C+Seon+Young&rft.au=Keam%2C+Bhumsuk&rft.date=2020-09-01&rft.issn=1226-3303&rft.eissn=2005-6648&rft.volume=35&rft.issue=5&rft.spage=1031&rft.epage=1044&rft_id=info:doi/10.3904%2Fkjim.2020.078&rft.externalDBID=n%2Fa&rft.externalDocID=10_3904_kjim_2020_078
thumbnail_l http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=1226-3303&client=summon
thumbnail_m http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=1226-3303&client=summon
thumbnail_s http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=1226-3303&client=summon