Targeting the Ubiquitin-Proteasome System for Cancer Therapeutics by Small-Molecule Inhibitors

• Published in: Cancers Vol. 13; no. 12; p. 3079
• Main Authors: LaPlante, Gabriel, Zhang, Wei
• Format: Journal Article
• Language: English
• Published: Basel MDPI AG 20.06.2021; MDPI
• Subjects: Cancer; Cell cycle; Chimeras; Degradation; DNA damage; Enzymes; Genomes; Homeostasis; Metabolism; Multiple myeloma; Mutation; Polypeptides; Proteasome inhibitors; Proteasomes; Protein turnover; Proteins; Proteolysis; Regulation; Review; Signal transduction; Tumor necrosis factor-TNF; Tumorigenesis; Ubiquitin

The ubiquitin-proteasome system (UPS) is a critical regulator of cellular protein levels and activity. It is, therefore, not surprising that its dysregulation is implicated in numerous human diseases, including many types of cancer. Moreover, since cancer cells exhibit increased rates of protein tur...