Fascin Inhibitors Decrease Cell Migration and Adhesion While Increase Overall Survival of Mice Bearing Bladder Cancers

• Published in: Cancers Vol. 13; no. 11; p. 2698
• Main Authors: Zhao, Zhankui, Wang, Yufeng, Zhang, J. Jillian, Huang, Xin-Yun
• Format: Journal Article
• Language: English
• Published: Basel MDPI AG 30.05.2021; MDPI
• Subjects: Actin; anti-PD-1; Apoptosis; Binding sites; Bladder cancer; Breast cancer; Cancer; Cancer therapies; Cell adhesion & migration; Cell growth; Cell migration; Chemotherapy; Cisplatin; cytoskeleton; fascin; Immune checkpoint inhibitors; Investigations; Medical prognosis; Metastases; Metastasis; Patients; PD-1 protein; Tumor cells; tumor metastasis; Tumors

Bladder cancer is one of the most common cancers in the world. Early stage bladder tumors can be surgically removed, but these patients usually have relapses. When bladder cancer becomes metastatic, survival is very low. There is an urgent need for new treatments for metastatic bladder cancers. Here...