Quantitative Methylation-Specific Polymerase Chain Reaction Gene Patterns in Urine Sediment Distinguish Prostate Cancer Patients From Control Subjects

• Published in: Journal of clinical oncology Vol. 23; no. 27; pp. 6569 - 6575
• Main Authors: Hoque, Mohammad Obaidul, Topaloglu, Ozlem, Begum, Shahnaz, Henrique, Rui, Rosenbaum, Eli, Van Criekinge, Wim, Westra, William H., Sidransky, David
• Format: Journal Article
• Language: English
• Published: Baltimore, MD American Society of Clinical Oncology 20.09.2005; Lippincott Williams & Wilkins
• Subjects: Adult; Aged; Aged, 80 and over; Biological and medical sciences; Biomarkers, Tumor - urine; Case-Control Studies; DNA Methylation; DNA, Neoplasm - genetics; DNA, Neoplasm - urine; Gene Expression Regulation, Neoplastic; Genes, Tumor Suppressor - physiology; Humans; Logistic Models; Male; Medical sciences; Middle Aged; Neoplasm Proteins - urine; Nephrology. Urinary tract diseases; Polymerase Chain Reaction - methods; Probability; Promoter Regions, Genetic; Prostatic Neoplasms - genetics; Prostatic Neoplasms - surgery; Prostatic Neoplasms - urine; Reference Values; Sensitivity and Specificity; Tumors; Tumors of the urinary system; Urinalysis; Urinary tract. Prostate gland; Human; Urine; Urinary system disease; Prostate disease; Malignant tumor; Polymerase chain reaction; Cancerology; Gene; Genetics; Molecular biology; Methylation; Male genital diseases; Prostate cancer; Quantitative analysis

Aberrant promoter hypermethylation of several known or putative tumor suppressor genes occurs frequently during the pathogenesis of prostate cancers and is a promising marker for cancer detection. We sought to develop a test for prostate cancer based on a quantitative methylation-specific polymerase...