Concomitant i.v. and oral clodronate in the relief of bone pain - a double-blind placebo-controlled study in patients with prostate cancer
Fifty-seven patients with advanced prostate cancer resistant to first-line hormonal therapy were treated with estramustine and additionally randomized for treatment with clodronate or placebo. Clodronate treatment was started with 5 days intravenous administration (300 mg day[-1]) and followed by or...
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| Published in | British journal of cancer Vol. 76; no. 7; pp. 939 - 942 |
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| Main Authors | , , , , , |
| Format | Journal Article |
| Language | English |
| Published |
Basingstoke
Nature Publishing Group
01.01.1997
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| Subjects | |
| Online Access | Get full text |
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| Abstract | Fifty-seven patients with advanced prostate cancer resistant to first-line hormonal therapy were treated with estramustine and additionally randomized for treatment with clodronate or placebo. Clodronate treatment was started with 5 days intravenous administration (300 mg day[-1]) and followed by oral treatment (1.6 g day[-1]) for 12 months. Skeletal pain relief was only about 10% better in the clodronate than in the placebo group. The results do not support the superiority of combined intravenous and oral treatment with clodronate compared with oral administration only. |
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| AbstractList | Fifty-seven patients with advanced prostate cancer resistant to first-line hormonal therapy were treated with estramustine and additionally randomized for treatment with clodronate or placebo. Clodronate treatment was started with 5 days intravenous administration (300 mg day[-1]) and followed by oral treatment (1.6 g day[-1]) for 12 months. Skeletal pain relief was only about 10% better in the clodronate than in the placebo group. The results do not support the superiority of combined intravenous and oral treatment with clodronate compared with oral administration only. Fifty-seven patients with advanced prostate cancer resistant to first-line hormonal therapy were treated with estramustine and additionally randomized for treatment with clodronate or placebo. Clodronate treatment was started with 5 days intravenous administration (300 mg day super(-1)) and followed by oral treatment (1.6 g day super(-1)) for 12 months. Skeletal pain relief was only about 10% better in the clodronate than in the placebo group. The results do not support the superiority of combined intravenous and oral treatment with clodronate compared with oral administration only. |
| Author | TAUBE, T RISTELI, L RISTELI, J KYLMÄLÄ, T ELOMAA, I TAMMELA, T. L. J |
| AuthorAffiliation | Department of Surgery, Tampere University Hospital, Finland |
| AuthorAffiliation_xml | – name: Department of Surgery, Tampere University Hospital, Finland |
| Author_xml | – sequence: 1 givenname: T surname: KYLMÄLÄ fullname: KYLMÄLÄ, T organization: Division of Urology, Department of Surgery, Tampere University Hospital, Finland – sequence: 2 givenname: T surname: TAUBE fullname: TAUBE, T organization: Department of Oncology, University of Helsinki, Finland – sequence: 3 givenname: T. L. J surname: TAMMELA fullname: TAMMELA, T. L. J organization: Division of Urology, Department of Surgery, Tampere University Hospital, Finland – sequence: 4 givenname: L surname: RISTELI fullname: RISTELI, L organization: Departments of Medical Biochemistry and Clinical Chemistry, University of Oulu, Finland – sequence: 5 givenname: J surname: RISTELI fullname: RISTELI, J organization: Departments of Medical Biochemistry and Clinical Chemistry, University of Oulu, Finland – sequence: 6 givenname: I surname: ELOMAA fullname: ELOMAA, I organization: Department of Oncology, University of Helsinki, Finland |
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| Keywords | Human Urinary system disease Intravenous administration Prostate disease Diseases of the osteoarticular system Oral administration Malignant tumor Chemotherapy Randomization Analgesic Pain Treatment Double blind study Advanced stage Bone Male genital diseases Prostate |
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| Title | Concomitant i.v. and oral clodronate in the relief of bone pain - a double-blind placebo-controlled study in patients with prostate cancer |
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