Single Transplanted Kidneys from A 90-Year-Old Deceased Donor Perform Acceptably at 1 Year

• Published in: Transplantation proceedings Vol. 43; no. 5; pp. 2107 - 2109
• Main Authors: Midtvedt, K, Namtvedt, T, Scott, H, Abedini, S, Rocke, J.C, Dørje, C, Foss, S, Christen, U, Hagness, M, Hartmann, A
• Format: Journal Article
• Language: English
• Published: Amsterdam Elsevier Inc 01.06.2011; Elsevier
• Subjects: Aged; Aged, 80 and over; Biological and medical sciences; Cadaver; Fundamental and applied biological sciences. Psychology; Fundamental immunology; Humans; Kidney Transplantation; Male; Medical sciences; Surgery; Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases; Tissue Donors; Tissue, organ and graft immunology; Suboptimal donor; Human; Medicine; Graft(material); Treatment; Urinary system; Surgery; Graft; Transplantation; Cadaver; Kidney
• ISSN: 0041-1345; 1873-2623
• DOI: 10.1016/j.transproceed.2011.01.192

Abstract Most centers are reluctant to accept expanded criteria donors above 70 to 75 years of age. We accepted kidneys from a 90-year-old male and report the 1-year outcome. The kidneys were used as single transplants and both had immediate graft function. Recipient A was a 71-year-old male, with cold ischemia time of 4 hours 49 minutes. One rejection was successfully treated with intravenous methylprednisolone. At 1 year, serum creatinine was 146 μmol/L with estimated glomerular filtration rate (eGFR) 41 mL/min. Recipient B was a 79-year-old male with known panel-reactive antibody positivity prior to transplantation. Cold ischemia time was 10 hours 4 minutes. He experienced no rejections. At 1 year serum-creatinine was 99 μmol/L with eGFR 63 mL/min. Both recipients performed a surveillance biopsy at 1 year with identical findings: interstitial fibrosis and tubular atrophy grade 1 with moderate to severe arteriolosclerosis. We conclude that both kidneys performed acceptably 1 year after engraftment. The use of old kidneys in old recipients gives them a properly functioning kidney and improves quality of life. Longer observation is needed.