The amalgam of naive CD4+ T cell transcriptional states is reconfigured by helminth infection to dampen the amplitude of the immune response - Even, Zachary; Meli, Alexandre P.; Tyagi, Antariksh; Vidyarthi, Aurobind; Briggs, Neima; de Kouchkovsky, Dimitri A.; Kong, Yong; Wang, Yaqiu; Waizman, Daniel A.; Rice, Tyler A.; De Kumar, Bony; Wang, Xusheng; et al. (Immunity (Cambridge, Mass.), 2024)
Keywords: Animals; CD4-Positive T-Lymphocytes - immunology; commensal microbiota; helminth; Helminthiasis - immunology; Interferon Type I - immunology; Interferon Type I - metabolism; Lymphocyte Activation - immunology; Mice; Mice, Inbred C57BL; naive T cell; Nippostrongylus - immunology; Receptors, Antigen, T-Cell - immunology; Receptors, Antigen, T-Cell - metabolism; Specific Pathogen-Free Organisms; Strongylida Infections - immunology; Strongylida Infections - parasitology; T cells; Transcription, Genetic; transcriptional heterogeneity; vaccines; naive T cell; helminth; commensal microbiota; transcriptional heterogeneity; T cells; vaccines