Chasing a ghost? - Issues with the determination of circulating levels of endotoxin in human blood

• Published in: Critical reviews in clinical laboratory sciences Vol. 53; no. 3; pp. 197 - 215
• Main Authors: Gnauck, Anne, Lentle, Roger Graham, Kruger, Marlena Cathorina
• Format: Journal Article
• Language: English
• Published: England Taylor & Francis 03.05.2016; Taylor & Francis Ltd
• Subjects: Bacterial infections; Bioassays; Blood; Blood tests; Clinical Chemistry Tests - methods; Disease; endotoxin; Endotoxins - blood; Gram-negative bacteria; Health; Humans; Limulus amebocyte lysate assay; Limulus Test; LPS; Medical diagnosis; Metabolic syndrome; Toxins; Limulus amebocyte lysate assay; Blood; LPS; endotoxin

Reliable quantification of bacterial products such as endotoxin is important for the diagnosis of Gram-negative infection and for the monitoring of its treatment. Further, it is important to identify patients with persistent subclinical level of bacterial products in their systemic circulation as da...