Classification and Treatment of Pediatric Gliomas in the Molecular Era

• Published in: Children (Basel) Vol. 8; no. 9; p. 739
• Main Author: Hauser, Peter
• Format: Journal Article
• Language: English
• Published: Basel MDPI AG 27.08.2021; MDPI
• Subjects: Age; Biopsy; Brain cancer; central nervous system (CNS) tumor; Chemotherapy; child; Classification; Cyclin-dependent kinases; diffuse intrinsic pontine glioma (DIPG); glioblastoma; Glioma; Kinases; Localization; Medical prognosis; Mutation; Nervous system; Pediatrics; Review; Signal transduction; Tumors

The overall survival of pediatric gliomas varies over a wide spectrum depending on the tumor grade. Low-grade gliomas have an excellent long-term survival, with a possible burden of surgery, irradiation, and chemotherapy; in contrast, high-grade gliomas generally have a short-term, devastating letha...