Classification and Treatment of Pediatric Gliomas in the Molecular Era

The overall survival of pediatric gliomas varies over a wide spectrum depending on the tumor grade. Low-grade gliomas have an excellent long-term survival, with a possible burden of surgery, irradiation, and chemotherapy; in contrast, high-grade gliomas generally have a short-term, devastating letha...

Full description

Saved in:
Bibliographic Details
Published inChildren (Basel) Vol. 8; no. 9; p. 739
Main Author Hauser, Peter
Format Journal Article
LanguageEnglish
Published Basel MDPI AG 27.08.2021
MDPI
Subjects
Age
Biopsy
Brain cancer
central nervous system (CNS) tumor
Chemotherapy
child
Classification
Cyclin-dependent kinases
diffuse intrinsic pontine glioma (DIPG)
glioblastoma
Glioma
Kinases
Localization
Medical prognosis
Mutation
Nervous system
Pediatrics
Review
Signal transduction
Tumors
Online AccessGet full text

Cover

More Information
Summary:The overall survival of pediatric gliomas varies over a wide spectrum depending on the tumor grade. Low-grade gliomas have an excellent long-term survival, with a possible burden of surgery, irradiation, and chemotherapy; in contrast, high-grade gliomas generally have a short-term, devastating lethal outcome. Recent advances in understanding their molecular background will transform the classification and therapeutic approaches of pediatric gliomas. Molecularly targeted treatments may acquire a leading role in the primary treatment of low-grade gliomas and may provide alternative therapeutic strategies for high-grade glioma cases in the attempt to avoid the highly unsuccessful conventional therapeutic approaches. This review aims to overview this progress.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 14
ObjectType-Review-3
content type line 23
ISSN:2227-9067
2227-9067
DOI:10.3390/children8090739