Responsive shape-shifting nanoarchitectonics and its application in tumor diagnosis and therapy

• Published in: Journal of controlled release Vol. 352; pp. 600 - 618
• Main Authors: Shao, Yaru, Xiang, Li, Zhang, Wenhui, Chen, Yuping
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 01.12.2022
• Subjects: Cell Line, Tumor; Drug Delivery Systems - methods; drugs; Humans; ingestion; Nanoarchitectonics; nanocarriers; Nanodrug delivery systems; Nanofibers; Nanoparticles; nanorods; Nanospheres; Nanotubes; neoplasms; Neoplasms - diagnosis; Neoplasms - drug therapy; Shape-shifting; Stimulus responsiveness; Tumor diagnosis and therapy; Nanoarchitectonics; Tumor diagnosis and therapy; Shape-shifting; Stimulus responsiveness; Nanodrug delivery systems

Nanodrug delivery system has a great application in the treatment of solid tumors by virtue of EPR effect, though its success in clinics is still limited by its poor extravasation, small intratumoral accumulation, and weak tumor penetration. The shape of nanoparticles (NPs) greatly affects their cir...