Transcription elongation defects link oncogenic SF3B1 mutations to targetable alterations in chromatin landscape - Boddu, Prajwal C.; Gupta, Abhishek K.; Roy, Rahul; De La Peña Avalos, Bárbara; Olazabal-Herrero, Anne; Neuenkirchen, Nils; Zimmer, Joshua T.; Chandhok, Namrata S.; King, Darren; Nannya, Yasuhito; Ogawa, Seishi; Lin, Haifan; et al. (Molecular cell, 2024)
Keywords: Animals; Chromatin - genetics; co-transcriptional splicing; DNA damage response; Humans; Mice; Mutation; Neoplasms; Phosphoproteins - genetics; Phosphoproteins - metabolism; R-loops; RNA polymerase II; RNA Polymerase II - genetics; RNA Polymerase II - metabolism; RNA Splicing - genetics; RNA Splicing Factors - genetics; RNA Splicing Factors - metabolism; SF3B1; Sin3/HDAC; spliceosome; transcription; U2AF1; WDR5; transcription; co-transcriptional splicing; DNA damage response; WDR5; U2AF1; Sin3/HDAC; spliceosome; R-loops; SF3B1; RNA polymerase II