Regulation of lipid and glucose homeostasis by mango tree leaf extract is mediated by AMPK and PI3K/AKT signaling pathways

• Published in: Food chemistry Vol. 141; no. 3; pp. 2896 - 2905
• Main Authors: Zhang, Yi, Liu, Xuefeng, Han, Lifeng, Gao, Xiumei, Liu, Erwei, Wang, Tao
• Format: Journal Article
• Language: English
• Published: Kidlington Elsevier Ltd 01.12.2013; Elsevier
• Subjects: 3T3-L1 Cells; AMP-Activated Protein Kinases - genetics; AMP-Activated Protein Kinases - metabolism; AMPK signaling pathway; Animals; Biological and medical sciences; Female; Food toxicology; Glucose - metabolism; Glucose and lipid regulation; Glucose Metabolism Disorders - drug therapy; Glucose Metabolism Disorders - enzymology; Glucose Metabolism Disorders - genetics; Glucose Metabolism Disorders - metabolism; Homeostasis - drug effects; Humans; Lipid Metabolism - drug effects; Male; Mangifera - chemistry; Mangifera indica; Medical sciences; Mice; Mice, Inbred C57BL; Oncogene Protein v-akt - genetics; Oncogene Protein v-akt - metabolism; Phosphatidylinositol 3-Kinases - genetics; Phosphatidylinositol 3-Kinases - metabolism; PI3 K/AKT signaling pathway; Plant Extracts - administration & dosage; Plant Extracts - chemistry; Plant Leaves - chemistry; PPAR gamma - genetics; PPAR gamma - metabolism; Signal Transduction - drug effects; Toxicology; Trees - chemistry; Triglycerides - metabolism; 3T3-L1 cells; Glucose and lipid regulation; PI3K/AKT signaling pathway; Mangifera indica; AMPK signaling pathway; PI3 K/AKT signaling pathway; Homeostasis; Lipids; Extract; Plant leaf; Glucose; In vitro; Signal transduction; Regulation(control); Dicotyledones; Angiospermae; Plant origin; Tree; Carbohydrate; Spermatophyta; Anacardiaceae

•Lipid and glucose homeostasis effects of mango leaf were reported firstly.•The homeostasis effects may be related to PI3K/AKT and AMPK signaling pathway.•Three kinds of benzophenone glucosides were detected in muscle and liver.•Effects of tissue distributed compounds were discussed. Ethanolic extra...