Regulation of lipid and glucose homeostasis by mango tree leaf extract is mediated by AMPK and PI3K/AKT signaling pathways

•Lipid and glucose homeostasis effects of mango leaf were reported firstly.•The homeostasis effects may be related to PI3K/AKT and AMPK signaling pathway.•Three kinds of benzophenone glucosides were detected in muscle and liver.•Effects of tissue distributed compounds were discussed. Ethanolic extra...

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Published inFood chemistry Vol. 141; no. 3; pp. 2896 - 2905
Main Authors Zhang, Yi, Liu, Xuefeng, Han, Lifeng, Gao, Xiumei, Liu, Erwei, Wang, Tao
Format Journal Article
LanguageEnglish
Published Kidlington Elsevier Ltd 01.12.2013
Elsevier
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Abstract •Lipid and glucose homeostasis effects of mango leaf were reported firstly.•The homeostasis effects may be related to PI3K/AKT and AMPK signaling pathway.•Three kinds of benzophenone glucosides were detected in muscle and liver.•Effects of tissue distributed compounds were discussed. Ethanolic extract of Mangifera indica (mango) dose-dependently decreased serum glucose and triglyceride in KK-Ay mice. Our in vitro and in vivo investigations revealed that the effect of mango leave extract (ME) on glucose and lipid homeostasis is mediated, at least in part, through the PI3K/AKT and AMPK signaling pathway. ME up-regulated the expression of PI3K, AKT and GYS genes by 2.0-fold, 3.2-fold, and 2.7-fold, respectively, leading to a decrease in glucose level. On the other hand, ME up-regulated AMPK and altered lipid metabolism. ME also down-regulated ACC (2.8-fold), HSL (1.6-fold), FAS (1.8-fold) and PPAR-γ (4.0-fold). Finally, we determined that active metabolites of benzophenone C-glucosides, Iriflophenone 3-C-β-glucoside and Foliamangiferoside A from ME, may play a dominant role in this integrated regulation of sugar and lipid homeostasis.
AbstractList Ethanolic extract of Mangifera indica (mango) dose-dependently decreased serum glucose and triglyceride in KK-A(y) mice. Our in vitro and in vivo investigations revealed that the effect of mango leave extract (ME) on glucose and lipid homeostasis is mediated, at least in part, through the PI3K/AKT and AMPK signaling pathway. ME up-regulated the expression of PI3K, AKT and GYS genes by 2.0-fold, 3.2-fold, and 2.7-fold, respectively, leading to a decrease in glucose level. On the other hand, ME up-regulated AMPK and altered lipid metabolism. ME also down-regulated ACC (2.8-fold), HSL (1.6-fold), FAS (1.8-fold) and PPAR-γ (4.0-fold). Finally, we determined that active metabolites of benzophenone C-glucosides, Iriflophenone 3-C-β-glucoside and Foliamangiferoside A from ME, may play a dominant role in this integrated regulation of sugar and lipid homeostasis.
•Lipid and glucose homeostasis effects of mango leaf were reported firstly.•The homeostasis effects may be related to PI3K/AKT and AMPK signaling pathway.•Three kinds of benzophenone glucosides were detected in muscle and liver.•Effects of tissue distributed compounds were discussed. Ethanolic extract of Mangifera indica (mango) dose-dependently decreased serum glucose and triglyceride in KK-Ay mice. Our in vitro and in vivo investigations revealed that the effect of mango leave extract (ME) on glucose and lipid homeostasis is mediated, at least in part, through the PI3K/AKT and AMPK signaling pathway. ME up-regulated the expression of PI3K, AKT and GYS genes by 2.0-fold, 3.2-fold, and 2.7-fold, respectively, leading to a decrease in glucose level. On the other hand, ME up-regulated AMPK and altered lipid metabolism. ME also down-regulated ACC (2.8-fold), HSL (1.6-fold), FAS (1.8-fold) and PPAR-γ (4.0-fold). Finally, we determined that active metabolites of benzophenone C-glucosides, Iriflophenone 3-C-β-glucoside and Foliamangiferoside A from ME, may play a dominant role in this integrated regulation of sugar and lipid homeostasis.
Author Zhang, Yi
Liu, Xuefeng
Wang, Tao
Liu, Erwei
Han, Lifeng
Gao, Xiumei
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  surname: Wang
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  email: wangt@263.net
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Issue 3
Keywords 3T3-L1 cells
Glucose and lipid regulation
PI3K/AKT signaling pathway
Mangifera indica
AMPK signaling pathway
PI3 K/AKT signaling pathway
Homeostasis
Lipids
Extract
Plant leaf
Glucose
In vitro
Signal transduction
Regulation(control)
Dicotyledones
Angiospermae
Plant origin
Tree
Carbohydrate
Spermatophyta
Anacardiaceae
Language English
License CC BY 4.0
Copyright © 2013. Published by Elsevier Ltd.
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Snippet •Lipid and glucose homeostasis effects of mango leaf were reported firstly.•The homeostasis effects may be related to PI3K/AKT and AMPK signaling...
Ethanolic extract of Mangifera indica (mango) dose-dependently decreased serum glucose and triglyceride in KK-A(y) mice. Our in vitro and in vivo...
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SubjectTerms 3T3-L1 Cells
AMP-Activated Protein Kinases - genetics
AMP-Activated Protein Kinases - metabolism
AMPK signaling pathway
Animals
Biological and medical sciences
Female
Food toxicology
Glucose - metabolism
Glucose and lipid regulation
Glucose Metabolism Disorders - drug therapy
Glucose Metabolism Disorders - enzymology
Glucose Metabolism Disorders - genetics
Glucose Metabolism Disorders - metabolism
Homeostasis - drug effects
Humans
Lipid Metabolism - drug effects
Male
Mangifera - chemistry
Mangifera indica
Medical sciences
Mice
Mice, Inbred C57BL
Oncogene Protein v-akt - genetics
Oncogene Protein v-akt - metabolism
Phosphatidylinositol 3-Kinases - genetics
Phosphatidylinositol 3-Kinases - metabolism
PI3 K/AKT signaling pathway
Plant Extracts - administration & dosage
Plant Extracts - chemistry
Plant Leaves - chemistry
PPAR gamma - genetics
PPAR gamma - metabolism
Signal Transduction - drug effects
Toxicology
Trees - chemistry
Triglycerides - metabolism
Title Regulation of lipid and glucose homeostasis by mango tree leaf extract is mediated by AMPK and PI3K/AKT signaling pathways
URI https://dx.doi.org/10.1016/j.foodchem.2013.05.121
https://www.ncbi.nlm.nih.gov/pubmed/23871039
https://search.proquest.com/docview/1411629531
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