Regulation of lipid and glucose homeostasis by mango tree leaf extract is mediated by AMPK and PI3K/AKT signaling pathways
•Lipid and glucose homeostasis effects of mango leaf were reported firstly.•The homeostasis effects may be related to PI3K/AKT and AMPK signaling pathway.•Three kinds of benzophenone glucosides were detected in muscle and liver.•Effects of tissue distributed compounds were discussed. Ethanolic extra...
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Published in | Food chemistry Vol. 141; no. 3; pp. 2896 - 2905 |
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Main Authors | , , , , , |
Format | Journal Article |
Language | English |
Published |
Kidlington
Elsevier Ltd
01.12.2013
Elsevier |
Subjects | |
Online Access | Get full text |
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Summary: | •Lipid and glucose homeostasis effects of mango leaf were reported firstly.•The homeostasis effects may be related to PI3K/AKT and AMPK signaling pathway.•Three kinds of benzophenone glucosides were detected in muscle and liver.•Effects of tissue distributed compounds were discussed.
Ethanolic extract of Mangifera indica (mango) dose-dependently decreased serum glucose and triglyceride in KK-Ay mice. Our in vitro and in vivo investigations revealed that the effect of mango leave extract (ME) on glucose and lipid homeostasis is mediated, at least in part, through the PI3K/AKT and AMPK signaling pathway. ME up-regulated the expression of PI3K, AKT and GYS genes by 2.0-fold, 3.2-fold, and 2.7-fold, respectively, leading to a decrease in glucose level. On the other hand, ME up-regulated AMPK and altered lipid metabolism. ME also down-regulated ACC (2.8-fold), HSL (1.6-fold), FAS (1.8-fold) and PPAR-γ (4.0-fold). Finally, we determined that active metabolites of benzophenone C-glucosides, Iriflophenone 3-C-β-glucoside and Foliamangiferoside A from ME, may play a dominant role in this integrated regulation of sugar and lipid homeostasis. |
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Bibliography: | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 |
ISSN: | 0308-8146 1873-7072 |
DOI: | 10.1016/j.foodchem.2013.05.121 |