Antioxidant activity from extra virgin olive oil via inhibition of hydrogen peroxide–mediated NADPH-oxidase 2 activation

• Published in: Nutrition (Burbank, Los Angeles County, Calif.) Vol. 55-56; pp. 36 - 40
• Main Authors: Carnevale, Roberto, Nocella, Cristina, Cammisotto, Vittoria, Bartimoccia, Simona, Monticolo, Roberto, D'Amico, Alessandra, Stefanini, Lucia, Pagano, Francesca, Pastori, Daniele, Cangemi, Roberto, Violi, Francesco
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01.11.2018; Elsevier Limited
• Subjects: Activation; antioxidant activity; Antioxidants; blood platelets; Cardiovascular diseases; Catalase; CYBB protein; EVOO; Experiments; extra-virgin olive oil; Gallic acid; Heart attacks; hydrogen; Hydrogen peroxide; in vitro studies; NAD(P)H oxidase; NAD(P)H oxidase (H2O2-forming); NADP (coenzyme); NOX2; Oils & fats; Olive oil; Oxidase; Oxidative stress; Platelets; Polyphenols; Scavenger activity; Scavenging; Supplements; Tocopherol; Variables; Vitamin E; Polyphenols; EVOO; Platelets; Vitamin E; Scavenger activity; NOX2

Extra virgin olive oil (EVOO) supplementation is associated with a significant reduction in cardiovascular disease but the underlying mechanism is still unclear. In platelets that were taken from healthy subjects (n = 5), agonist-induced hydrogen peroxide (H2O2) production and NADPH oxidase 2 (NOX2)...