The PVT1-214/miR-671-5p/SLC45A4 signaling axis regulates cell proliferation in human gastric cancer

• Published in: World journal of surgical oncology Vol. 23; no. 1; pp. 158 - 13
• Main Authors: Yan, Wei, Wang, Huizhen, Zhao, Yong, Zhang, Weitong, Li, Yongxiang
• Format: Journal Article
• Language: English
• Published: England BioMed Central Ltd 24.04.2025; BMC
• Subjects: Animals; Antisense RNA; Apoptosis; Biomarkers, Tumor - genetics; Biomarkers, Tumor - metabolism; Cancer; Cell Line, Tumor; Cell Movement; Cell Proliferation; Female; Gastric cancer; Gene Expression Regulation, Neoplastic; Humans; Long noncoding RNA; Luciferase; Male; Membrane Transport Proteins - genetics; Membrane Transport Proteins - metabolism; Metastasis; Mice; Mice, Inbred BALB C; Mice, Nude; MicroRNAs - genetics; MicroRNAs - metabolism; Middle Aged; miR-671-5p; Prognosis; Protein binding; PVT1-214; RNA, Long Noncoding - genetics; RNA, Long Noncoding - metabolism; Signal Transduction; SLC45A4; Stomach cancer; Stomach Neoplasms - genetics; Stomach Neoplasms - metabolism; Stomach Neoplasms - pathology; Tumor Cells, Cultured; Xenograft Model Antitumor Assays; China; America; SLC45A4; Long noncoding RNA; miR-671-5p; Gastric cancer; PVT1-214

Long non-coding RNA PVT1 (lncRNA PVT1) serves as a carcinogenic regulatory factor in several cancers; however, the expression and function of its transcriptional isomer PVT1-214 in gastric cancer (GC) are poorly understood. PVT1-214 and miR-671-5p levels in GC cells and tissues were analyzed through...