Exploring chitosan nanoparticles as effective inhibitors of antibiotic resistant skin microorganisms – From in vitro to ex vitro testing

• Published in: Carbohydrate polymers Vol. 201; pp. 340 - 346
• Main Authors: Costa, Eduardo M., Silva, Sara, Veiga, Mariana, Tavaria, Freni K., Pintado, Maria M.
• Format: Journal Article
• Language: English
• Published: England Elsevier Ltd 01.12.2018
• Subjects: Acinetobacter baumannii - growth & development; Acinetobacter Infections - drug therapy; Acinetobacter Infections - microbiology; Antibiofilm; antibiotic resistance; antibiotics; Antimicrobial; biofilm; Cell Line; chitosan; Chitosan - chemistry; Chitosan - pharmacology; Chitosan nanoparticles; cross infection; Drug Resistance, Bacterial - drug effects; HaCat infection; Humans; Keratinocytes - metabolism; Keratinocytes - microbiology; Keratinocytes - pathology; MDR; microorganisms; nanoparticles; Nanoparticles - chemistry; Nanoparticles - therapeutic use; pathogens; plankton; plate count; quorum sensing; Skin Diseases, Bacterial - drug therapy; Skin Diseases, Bacterial - microbiology; Antimicrobial; MDR; HaCat infection; Chitosan nanoparticles; Antibiofilm

•Chitosan nanoparticles inhibited planktonic and sessile growth.•Nanoparticles had an average MIC of 1.5 mg/mL and an average MBC of 4.2 mg/mL.•NPs produced, on average, biofilm formation inhibitions superior to 50%.•Nanoparticles effectively disrupt the C. violaceum quorum sensing reporter system.•...