Smart biomimetic metal organic frameworks based on ROS-ferroptosis-glycolysis regulation for enhanced tumor chemo-immunotherapy

• Published in: Journal of controlled release Vol. 334; pp. 21 - 33
• Main Authors: Yang, Jie, Ma, Siyu, Xu, Rui, Wei, Yawen, Zhang, Jun, Zuo, Tiantian, Wang, Zhihua, Deng, Huizi, Yang, Ning, Shen, Qi
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 10.06.2021
• Subjects: biomimetics; cell membranes; coordination polymers; doxorubicin; Ferroptosis; glucose; glucose oxidase; glutathione; Glycolysis; Immunogenic cell death (ICD); immunogenicity; immunosuppression; Immunosuppressive microenvironment (TIME); immunotherapy; lactic acid; ligands; Metal organic framework (MOF); neoplasm cells; neoplasms; Reactive oxygen species (ROS); Glycolysis; Ferroptosis; Immunosuppressive microenvironment (TIME); Metal organic framework (MOF); Immunogenic cell death (ICD); Reactive oxygen species (ROS)

Antitumor immunotherapy is limited by low tumor immunogenicity and immunosuppressive microenvironment (TIME), which could be improved by “ROS-ferroptosis-glycolysis regulation” strategy. Herein, a cancer cell membrane coated metal organic framework (MOF) loading with glucose oxidase (GOx) and doxoru...