Clearance of two organic nanoparticles from the brain via the paravascular pathway

• Published in: Journal of controlled release Vol. 322; pp. 31 - 41
• Main Authors: Gu, Xiao, Song, Qingxiang, Zhang, Qian, Huang, Meng, Zheng, Mengna, Chen, Juan, Wei, Dan, Chen, Jun, Wei, Xunbin, Chen, Hongzhuan, Zheng, Gang, Gao, Xiaoling
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 10.06.2020
• Subjects: Alzheimer disease; Aquaporin-4; blood-brain barrier; brain; Brain clearance; drugs; Glymphatic system; half life; high density lipoprotein; mice; Microglia; Nanoparticles; polyethylene glycol; therapeutics; transgenic animals; Ab; BBB; SR101; PEG-PLA; DiI; ApoE3; PLX3397; AQP4; GM1; DiO; Nanoparticles; D-cervical LN; CSF; S-cervical LN; ID; DMPC; Brain clearance; WT; ISF; AD; cou6; KO; rHDL; Microglia; Glymphatic system; Aquaporin-4; TCA; CL-lip; ACZ; DiD

The elaboration of nanotechnology offers valuable therapeutic options to overcome the blood-brain barrier and enable the treatment of brain diseases. However, to date, limit work has been done to reveal the fate of nanoparticles within the brain, which largely hinders their safe and effective applic...