Correlation of Early-Phase F-18 Florapronal PET with F-18 FDG PET in Alzheimer’s Disease and Normal Brain

Purpose F-18 florapronol (FPN) is the commercially recognized beta-amyloid positron emission tomography (PET) radiotracer in Korea. This study compared the early F-18 florapronol PET with F-18 fluorodeoxyglucose (FDG) PET between healthy controls (HC) and Alzheimer’s dementia (AD) patients. Methods...

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Published inNuclear medicine and molecular imaging Vol. 53; no. 5; pp. 328 - 333
Main Authors Jeong, Jieun, Jeong, Young Jin, Park, Kyung Won, Kang, Do-Young
Format Journal Article
LanguageEnglish
Published Berlin/Heidelberg Springer Berlin Heidelberg 01.10.2019
Springer Nature B.V
대한핵의학회
Subjects
Brain
Cardiology
Cerebellum
Computed tomography
Correlation coefficients
Emission analysis
Fluorine isotopes
Image acquisition
Imaging
Mathematical analysis
Medical imaging
Medicine
Medicine & Public Health
Nuclear Medicine
Oncology
Original
Original Article
Orthopedics
Positron emission
Radioactive tracers
Radioisotopes
Radiology
Tomography
방사선과학
Dual time
F-18 FDG
Alzheimer’s disease
F-18 florapronol
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Abstract Purpose F-18 florapronol (FPN) is the commercially recognized beta-amyloid positron emission tomography (PET) radiotracer in Korea. This study compared the early F-18 florapronol PET with F-18 fluorodeoxyglucose (FDG) PET between healthy controls (HC) and Alzheimer’s dementia (AD) patients. Methods A total of 29 subjects (15 HC and 14 AD subjects) underwent F-18 FPN PET and F-18 FDG PET. F-18 FDG PET image was acquired from 30 to 60 min and F-18 FPN PET for 0 to 10 min. F-18 FPN and F-18 FDG images were spatially normalized with transformation matrices obtained from individual CT images and standardized uptake value ration (SUVR) from cerebellum area, and the global mean was calculated using PMOD 3.6. Pearson’s correlation coefficients between F-18 FDG and early F-18 FPN for predefined cortical brain regions were calculated. Results We compared the F-18 FDG and F-18 FPN for SUVR of a specific region in global mean normalization and cerebellum normalization, and most of the correlation coefficient was higher in global mean normalization. In global mean normalization, the correlation coefficient for SUVR of HC was higher than that of AD in all brain regions. Conclusions Early F-18 FPN study can be used as a proxy marker for the F-18 FDG PET.
AbstractList PurposeF-18 florapronol (FPN) is the commercially recognized beta-amyloid positron emission tomography (PET) radiotracer in Korea. This study compared the early F-18 florapronol PET with F-18 fluorodeoxyglucose (FDG) PET between healthy controls (HC) and Alzheimer’s dementia (AD) patients.MethodsA total of 29 subjects (15 HC and 14 AD subjects) underwent F-18 FPN PET and F-18 FDG PET. F-18 FDG PET image was acquired from 30 to 60 min and F-18 FPN PET for 0 to 10 min. F-18 FPN and F-18 FDG images were spatially normalized with transformation matrices obtained from individual CT images and standardized uptake value ration (SUVR) from cerebellum area, and the global mean was calculated using PMOD 3.6. Pearson’s correlation coefficients between F-18 FDG and early F-18 FPN for predefined cortical brain regions were calculated.ResultsWe compared the F-18 FDG and F-18 FPN for SUVR of a specific region in global mean normalization and cerebellum normalization, and most of the correlation coefficient was higher in global mean normalization. In global mean normalization, the correlation coefficient for SUVR of HC was higher than that of AD in all brain regions.ConclusionsEarly F-18 FPN study can be used as a proxy marker for the F-18 FDG PET.
F-18 florapronol (FPN) is the commercially recognized beta-amyloid positron emission tomography (PET) radiotracer in Korea. This study compared the early F-18 florapronol PET with F-18 fluorodeoxyglucose (FDG) PET between healthy controls (HC) and Alzheimer's dementia (AD) patients.PURPOSEF-18 florapronol (FPN) is the commercially recognized beta-amyloid positron emission tomography (PET) radiotracer in Korea. This study compared the early F-18 florapronol PET with F-18 fluorodeoxyglucose (FDG) PET between healthy controls (HC) and Alzheimer's dementia (AD) patients.A total of 29 subjects (15 HC and 14 AD subjects) underwent F-18 FPN PET and F-18 FDG PET. F-18 FDG PET image was acquired from 30 to 60 min and F-18 FPN PET for 0 to 10 min. F-18 FPN and F-18 FDG images were spatially normalized with transformation matrices obtained from individual CT images and standardized uptake value ration (SUVR) from cerebellum area, and the global mean was calculated using PMOD 3.6. Pearson's correlation coefficients between F-18 FDG and early F-18 FPN for predefined cortical brain regions were calculated.METHODSA total of 29 subjects (15 HC and 14 AD subjects) underwent F-18 FPN PET and F-18 FDG PET. F-18 FDG PET image was acquired from 30 to 60 min and F-18 FPN PET for 0 to 10 min. F-18 FPN and F-18 FDG images were spatially normalized with transformation matrices obtained from individual CT images and standardized uptake value ration (SUVR) from cerebellum area, and the global mean was calculated using PMOD 3.6. Pearson's correlation coefficients between F-18 FDG and early F-18 FPN for predefined cortical brain regions were calculated.We compared the F-18 FDG and F-18 FPN for SUVR of a specific region in global mean normalization and cerebellum normalization, and most of the correlation coefficient was higher in global mean normalization. In global mean normalization, the correlation coefficient for SUVR of HC was higher than that of AD in all brain regions.RESULTSWe compared the F-18 FDG and F-18 FPN for SUVR of a specific region in global mean normalization and cerebellum normalization, and most of the correlation coefficient was higher in global mean normalization. In global mean normalization, the correlation coefficient for SUVR of HC was higher than that of AD in all brain regions.Early F-18 FPN study can be used as a proxy marker for the F-18 FDG PET.CONCLUSIONSEarly F-18 FPN study can be used as a proxy marker for the F-18 FDG PET.
F-18 florapronol (FPN) is the commercially recognized beta-amyloid positron emission tomography (PET) radiotracer in Korea. This study compared the early F-18 florapronol PET with F-18 fluorodeoxyglucose (FDG) PET between healthy controls (HC) and Alzheimer's dementia (AD) patients. A total of 29 subjects (15 HC and 14 AD subjects) underwent F-18 FPN PET and F-18 FDG PET. F-18 FDG PET image was acquired from 30 to 60 min and F-18 FPN PET for 0 to 10 min. F-18 FPN and F-18 FDG images were spatially normalized with transformation matrices obtained from individual CT images and standardized uptake value ration (SUVR) from cerebellum area, and the global mean was calculated using PMOD 3.6. Pearson's correlation coefficients between F-18 FDG and early F-18 FPN for predefined cortical brain regions were calculated. We compared the F-18 FDG and F-18 FPN for SUVR of a specific region in global mean normalization and cerebellum normalization, and most of the correlation coefficient was higher in global mean normalization. In global mean normalization, the correlation coefficient for SUVR of HC was higher than that of AD in all brain regions. Early F-18 FPN study can be used as a proxy marker for the F-18 FDG PET.
Purpose F-18 florapronol (FPN) is the commercially recognized beta-amyloid positron emission tomography (PET) radiotracer in Korea. This study compared the early F-18 florapronol PET with F-18 fluorodeoxyglucose (FDG) PET between healthy controls (HC) and Alzheimer’s dementia (AD) patients. Methods A total of 29 subjects (15 HC and 14 AD subjects) underwent F-18 FPN PET and F-18 FDG PET. F-18 FDG PET image was acquired from 30 to 60 min and F-18 FPN PET for 0 to 10 min. F-18 FPN and F-18 FDG images were spatially normalized with transformation matrices obtained from individual CT images and standardized uptake value ration (SUVR) from cerebellum area, and the global mean was calculated using PMOD 3.6. Pearson’s correlation coefficients between F-18 FDG and early F-18 FPN for predefined cortical brain regions were calculated. Results We compared the F-18 FDG and F-18 FPN for SUVR of a specific region in global mean normalization and cerebellum normalization, and most of the correlation coefficient was higher in global mean normalization. In global mean normalization, the correlation coefficient for SUVR of HC was higher than that of AD in all brain regions. Conclusions Early F-18 FPN study can be used as a proxy marker for the F-18 FDG PET.
Purpose F-18 florapronol (FPN) is the commercially recognized beta-amyloid positron emission tomography (PET) radiotracer in Korea. This study compared the early F-18 florapronol PET with F-18 fluorodeoxyglucose (FDG) PET between healthy controls (HC) and Alzheimer’s dementia (AD) patients. Methods A total of 29 subjects (15 HC and 14 AD subjects) underwent F-18 FPN PET and F-18 FDG PET. F-18 FDG PET image was acquired from 30 to 60 min and F-18 FPN PET for 0 to 10 min. F-18 FPN and F-18 FDG images were spatially normalized with transformation matrices obtained from individual CTimages and standardized uptake value ration (SUVR) from cerebellum area, and the global mean was calculated using PMOD 3.6. Pearson’s correlation coefficients between F-18 FDG and early F-18 FPN for predefined cortical brain regions were calculated. Results We compared the F-18 FDG and F-18 FPN for SUVR of a specific region in global mean normalization and cerebellum normalization, and most of the correlation coefficient was higher in global mean normalization. In global mean normalization, the correlation coefficient for SUVR of HC was higher than that of AD in all brain regions. Conclusions Early F-18 FPN study can be used as a proxy marker for the F-18 FDG PET. KCI Citation Count: 0
Author Jeong, Jieun
Jeong, Young Jin
Kang, Do-Young
Park, Kyung Won
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Keywords Dual time
F-18 FDG
Alzheimer’s disease
F-18 florapronol
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Snippet Purpose F-18 florapronol (FPN) is the commercially recognized beta-amyloid positron emission tomography (PET) radiotracer in Korea. This study compared the...
F-18 florapronol (FPN) is the commercially recognized beta-amyloid positron emission tomography (PET) radiotracer in Korea. This study compared the early F-18...
PurposeF-18 florapronol (FPN) is the commercially recognized beta-amyloid positron emission tomography (PET) radiotracer in Korea. This study compared the...
Purpose F-18 florapronol (FPN) is the commercially recognized beta-amyloid positron emission tomography (PET) radiotracer in Korea. This study compared the...
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SubjectTerms Brain
Cardiology
Cerebellum
Computed tomography
Correlation coefficients
Emission analysis
Fluorine isotopes
Image acquisition
Imaging
Mathematical analysis
Medical imaging
Medicine
Medicine & Public Health
Nuclear Medicine
Oncology
Original
Original Article
Orthopedics
Positron emission
Radioactive tracers
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방사선과학
Title Correlation of Early-Phase F-18 Florapronal PET with F-18 FDG PET in Alzheimer’s Disease and Normal Brain
URI https://link.springer.com/article/10.1007/s13139-019-00612-y
https://www.ncbi.nlm.nih.gov/pubmed/31723362
https://www.proquest.com/docview/2310696990
https://www.proquest.com/docview/2314558688
https://pubmed.ncbi.nlm.nih.gov/PMC6821898
https://www.kci.go.kr/kciportal/ci/sereArticleSearch/ciSereArtiView.kci?sereArticleSearchBean.artiId=ART002515007
Volume 53
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ispartofPNX Nuclear Medicine and Molecular Imaging , 2019, 53(5), , pp.328-333
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