Efficacy of Metreleptin in Obese Patients With Type 2 Diabetes: Cellular and Molecular Pathways Underlying Leptin Tolerance

• Published in: Diabetes (New York, N.Y.) Vol. 60; no. 6; pp. 1647 - 1656
• Main Authors: Moon, Hyun-Seuk, Matarese, Giuseppe, Brennan, Aoife M., Chamberland, John P., Liu, Xiaowen, Fiorenza, Christina G., Mylvaganam, Geetha H., Abanni, Luisa, Carbone, Fortunata, Williams, Catherine J., De Paoli, Alex M., Schneider, Benjamin E., Mantzoros, Christos S.
• Format: Journal Article
• Language: English
• Published: Alexandria, VA American Diabetes Association 01.06.2011
• Subjects: Adipocytes - drug effects; Adipocytes - metabolism; Adult; Biological and medical sciences; Biopsy; Blotting, Western; Body fat; Body Weight - drug effects; Cells, Cultured; Diabetes; Diabetes Mellitus, Type 2 - blood; Diabetes Mellitus, Type 2 - drug therapy; Diabetes. Impaired glucose tolerance; Diet; Double-Blind Method; Endocrine pancreas. Apud cells (diseases); Endocrinopathies; Endoplasmic reticulum; Enzyme-Linked Immunosorbent Assay; Etiopathogenesis. Screening. Investigations. Target tissue resistance; Female; Glycated Hemoglobin - metabolism; Humans; Immunohistochemistry; Insulin resistance; Leptin - analogs & derivatives; Leptin - blood; Leptin - immunology; Leptin - therapeutic use; Male; Medical sciences; Metabolic diseases; Metabolism; Middle Aged; Obesity; Obesity - blood; Obesity - drug therapy; Phosphorylation - drug effects; Receptors, Leptin - blood; Research design; s in Diabetes; Signal Transduction - drug effects; STAT3 Transcription Factor - metabolism; Weight control; Endocrinopathy; Type 2 diabetes; Human; Obesity; Leptin; Nutrition disorder; Tolerance; Metabolic diseases; Adipokine; Nutritional status

Metreleptin has been efficacious in improving metabolic control in patients with lipodystrophy, but its efficacy has not been tested in obese patients with type 2 diabetes. We studied the role of leptin in regulating the endocrine adaptation to long-term caloric deprivation and weight loss in obese...