human ClC-4 protein, a member of the CLC chloride channel/transporter family, is localized to the endoplasmic reticulum by its N-terminus

• Published in: The FASEB journal Vol. 20; no. 13; pp. 2390 - 2392
• Main Authors: Okkenhaug, Hanneke, Weylandt, Karsten-Henrich, Carmena, David, Wells, Dominic J, Higgins, Christopher F, Sardini, Alessandro
• Format: Journal Article
• Language: English
• Published: United States The Federation of American Societies for Experimental Biology 01.11.2006
• Subjects: Animals; Cell Line; Chloride Channels - chemistry; Chloride Channels - genetics; Chloride Channels - physiology; Endoplasmic Reticulum - physiology; Humans; Immunohistochemistry; Kidney; Mice; Mice, Inbred C57BL; Microscopy, Confocal; Muscle Fibers, Skeletal - physiology; Muscle, Skeletal - physiology; Recombinant Proteins - chemistry; Recombinant Proteins - metabolism; Transfection

Despite considerable similarity in their amino acid sequences and structural features, the mammalian members of the CLC chloride channel/transporter family have different subcellular locations. The subcellular location and function of one of these members, hClC-4, is controversial. To characterize i...