Genetic determinants of lipid-lowering response to atorvastatin therapy in an Indian population

• Published in: Journal of clinical pharmacy and therapeutics Vol. 41; no. 3; pp. 329 - 333
• Main Authors: Kadam, P., Ashavaid, T. F., Ponde, C. K., Rajani, R. M.
• Format: Journal Article
• Language: English
• Published: England Blackwell Publishing Ltd 01.06.2016; Hindawi Limited
• Subjects: Aged; Alleles; atorvastatin; Atorvastatin Calcium - pharmacology; Atorvastatin Calcium - therapeutic use; Cholesterol, LDL - blood; Female; Genetic Variation; Genotype; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors - pharmacology; Hydroxymethylglutaryl-CoA Reductase Inhibitors - therapeutic use; Hypercholesterolemia - drug therapy; India; low-density lipoprotein-cholesterol; Male; Middle Aged; Pharmacogenetics; Polymorphism, Single Nucleotide; polymorphisms; Treatment Outcome; atorvastatin; polymorphisms; pharmacogenetics; low-density lipoprotein-cholesterol

Summary What is known and objective Statins form the backbone of lipid‐lowering therapy for the prevention of cardiovascular disease. However, there is large interindividual variability in clinical response to statin treatment. Several gene variants that can be aligned to either the pharmacokinetics...