Platelet-derived growth factor stimulates bone fill and rate of attachment level gain: results of a large multicenter randomized controlled trial

• Published in: Journal of periodontology (1970) Vol. 76; no. 12; p. 2205
• Main Authors: Nevins, Myron, Giannobile, William V, McGuire, Michael K, Kao, Richard T, Mellonig, James T, Hinrichs, James E, McAllister, Bradley S, Murphy, Kevin S, McClain, Pamela K, Nevins, Marc L, Paquette, David W, Han, Thomas J, Reddy, Michael S, Lavin, Philip T, Genco, Robert J, Lynch, Samuel E
• Format: Journal Article
• Language: English
• Published: United States 01.12.2005
• Subjects: Adult; Aged; Alveolar Bone Loss - surgery; Alveolar Process - physiopathology; Bone Regeneration - drug effects; Bone Substitutes - therapeutic use; Calcium Phosphates - therapeutic use; Female; Follow-Up Studies; Gingival Recession - surgery; Humans; Male; Middle Aged; Periodontal Attachment Loss - surgery; Periodontal Pocket - surgery; Platelet-Derived Growth Factor - therapeutic use; Prospective Studies; Proto-Oncogene Proteins c-sis; Recombinant Proteins; Safety; Treatment Outcome; Wound Healing - drug effects

Growth factors are generally accepted to be essential mediators of tissue repair via well-established mechanisms of action that include stimulatory effects on angiogenesis and cellular proliferation, ingrowth, differentiation, and matrix biosynthesis. The aim of this study was to evaluate in a large...