Placenta‐ versus bone‐marrow‐derived mesenchymal cells for the repair of segmental bone defects in a rabbit model

• Published in: The FEBS journal Vol. 279; no. 13; pp. 2455 - 2465
• Main Authors: Fan, Zhao‐Xin, Lu, Yao, Deng, Li, Li, Xiu‐Qun, Zhi, Wei, Li‐Ling, Jesse, Yang, Zhi‐Ming, Xie, Hui‐Qi
• Format: Journal Article
• Language: English
• Published: Oxford, UK Blackwell Publishing Ltd 01.07.2012
• Subjects: Alkaline Phosphatase - metabolism; Animals; Biomedical materials; bone defect; Bone marrow; Bone Marrow Cells - cytology; Bone Regeneration; Cell Differentiation; Cells, Cultured; Coculture Techniques; Collagen Type I - metabolism; Female; Femur - abnormalities; Immunoenzyme Techniques; Immunohistochemistry; mesenchymal stem cells; Mesenchymal Stromal Cells - cytology; Osteogenesis - physiology; placenta; Placenta - cytology; Pregnancy; Rabbits; Stem cells; Tissue Engineering; Wound Healing

Tissue‐engineered bones (TEBs) constructed with bone‐marrow‐derived mesenchymal stem cells (BMSCs) seeded on biomaterial scaffolds have achieved good results for bone defect repair in both animal experiments and clinical trials. This has been limited, however, by the source and quantity of BMSCs. We...