SIRT1 transgenic mice show phenotypes resembling calorie restriction

• Published in: Aging cell Vol. 6; no. 6; pp. 759 - 767
• Main Authors: Bordone, Laura, Cohen, Dena, Robinson, Ashley, Motta, Maria Carla, Van Veen, Ed, Czopik, Agnieszka, Steele, Andrew D., Crowe, Hayley, Marmor, Stephen, Luo, Jianyuan, Gu, Wei, Guarente, Leonard
• Format: Journal Article
• Language: English
• Published: Oxford, UK Blackwell Publishing Ltd 01.12.2007
• Subjects: Adipokines - blood; Animals; Blood Glucose - analysis; Caloric Restriction; calorie restriction; Cholesterol - blood; Insulin - blood; Longevity - genetics; Mice; Mice, Transgenic; Phenotype; SIRT1; Sirtuin 1; Sirtuins - genetics; Sirtuins - metabolism; transgenic mice; Up-Regulation

Summary We generated mice that overexpress the sirtuin, SIRT1. Transgenic mice have been generated by knocking in SIRT1 cDNA into the β‐actin locus. Mice that are hemizygous for this transgene express normal levels of β‐actin and higher levels of SIRT1 protein in several tissues. Transgenic mice dis...